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The Metabolism of Insulin Receptors: Internalization, Degradation, and Recycling

  • Kim A. Heidenreich
  • Jerrold M. Olefsky

Abstract

The concept that receptors function as recognition sites for polypeptide hormones and neurotransmitters on plasma membranes of target cells originated during the early 1900s.(1) The theory that emerged was that binding of hormone to its receptor on the outer face of the membrane is the initial step in hormonal action, which triggers a transmembrane signal such as generation of a second messenger. This theory has now been expanded, since receptors subserve a greater role in hormone function and metabolism. In addition to hormone recognition, receptors mediate the internalization(2–5) and degradation(6) of hormones. This has been documented for many peptide hormone—receptor systems(7) and the process appears to be similar to receptor-mediated endocytosis of other molecules such as low-density lipoproteins,(8) asialoglycoproteins,(9) and α2-macroglobulins.(10)

Keywords

Insulin Receptor Insulin Analog Apparent Molecular Weight Tryptic Fragment Photoaffinity Label 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Kim A. Heidenreich
    • 1
  • Jerrold M. Olefsky
    • 1
  1. 1.Department of MedicineUniversity of California at San DiegoLa JollaUSA

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