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Insulin Action on the (Na+,K+)ATPase

  • Marilyn D. Resh

Abstract

Reduction of serum potassium levels was one of the earliest recognized effects of insulin administration in vivo. (1) There is now substantial evidence to indicate that this hypokalemic effect is due to enhanced K+ uptake into insulin’s target tissues and that intracellular concentrations of Na+ and K+ are altered as a result of insulin treatment. Almost all eukaryotic cells maintain high cytoplasmic K+ concentrations and low Na+ concentrations relative to the extracellular fluid. These cationic gradients have a profound influence on cellular volume and osmotic pressure,(2) membrane potential(3) protein synthesis, (4) and the transport of nonelectrolytes.(5) Active transport of Na+ and K+ ions across the plasma membrane is mediated by the Na+ and K+ ion-activated adenosine triphosphatase [(Na+,K+)ATPase or Na+ pump],(6–8) first identified in crab nerve membranes by Skou in 1957.(9) Under physiological conditions, this membrane-bound enzyme couples the influx of two K+ ions and the efflux of three Na+; ions to the hydrolysis of one molecule of ATP.(6–8)

Keywords

ATPase Activity Glucose Transporter Insulin Action Insulin Treatment Insulin Binding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Marilyn D. Resh
    • 1
  1. 1.The Biological LaboratoriesHarvard UniversityCambridgeUSA

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