Insulin Action on Membrane Components: The Glucose Transporter and the Type II Insulinlike Growth Factor Receptor

  • Yoshitomo Oka
  • Michael P. Czech


It has been known for more than three decades that a major cellular target of insulin action is glucose transport activity.(1,2) In two major target tissues—muscle and fat—insulin action on hexose transport occurs within minutes and results in up to 10-fold stimulations (for reviews, see ref. 3 and 4). The insulin-responsive glucose transport systems are of the facilitated diffusion type, while the Na+-dependent, active glucose transport systems appear not to be insulin sensitive. Interestingly, in most cell types other than muscle and fat containing glucose transporters that operate by a facilitated diffusion mechanism, insulin appears to have little or no effect on glucose transport. Nevertheless, the effect of insulin on glucose uptake in muscle and adipose tissue contributes significantly to the hypoglycemic effect of insulin in intact animals and man. Therefore, the underlying biochemical mechanism of insulin action on hexose transport is of clear physiological and clinical significance.


Insulin Action Scatchard Analysis Hexose Transporter Plasma Membrane Fraction Photoaffinity Label 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Yoshitomo Oka
    • 1
  • Michael P. Czech
    • 1
  1. 1.Department of BiochemistryUniversity of Massachusetts Medical SchoolWorcesterUSA

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