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Hormonal Regulation of Phosphoenolpyruvate Carboxykinase Gene Expression

  • David S. Loose
  • Anthony Wynshaw-Boris
  • Herman M. Meisner
  • Yaacov Hod
  • Richard W. Hanson

Abstract

Glucose homeostasis in all vertebrates involves the integration of a number of metabolic processes that are under hormonal control. A key element in this process is hepatic and renal gluconeogenesis, which provides the major source of blood glucose during starvation.(1) Tissues such as the red blood cells, brain, and kidney medulla are metabolically dependent on a continued source of glucose, a fact that underlines the importance of proper regulation of gluconeogenesis for the survival of the organism. It is not therefore surprising that a number of hormones, including insulin, glucagon, glucocorticoids, and thyroid hormone, all play a role in coordinating glucose homeostasis by controlling gluconeogenesis.

Keywords

Thymidine Kinase Hormonal Regulation Synthesis Rate Chimeric Gene Transcription Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • David S. Loose
    • 1
  • Anthony Wynshaw-Boris
    • 1
  • Herman M. Meisner
    • 1
  • Yaacov Hod
    • 1
  • Richard W. Hanson
    • 1
  1. 1.Department of BiochemistryCase Western Reserve University School of MedicineClevelandUSA

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