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Regulation of Acetyl CoA Carboxylase by Insulin and Other Hormones

  • Lee A. Witters

Abstract

Acetyl CoA carboxylase (E.C. 6.4.1.2.) catalyzes the first committed step of fatty acid synthesis, namely, the biotin-dependent conversion of acetyl CoA to malonyl CoA by the fixation of bicarbonate. Given this pivotal position, the modulation of its activity serves as an important locus for the regulation of the rate of fatty acid synthesis. It seems clear that it is not the only potential locus, for several other more proximal steps leading to the generation of cytoplasmic acetyl CoA are also subject to acute regulation. These include the uptake of glucose and other precursor molecules, as well as the reactions catalyzed by phosphofructokinase, pyruvate kinase, and pyruvate dehydrogenase.(l) However, the study of the regulation of acetyl CoA carboxylase (ACC) has proved an excellent reporter system for detailing the mechanisms by which several hormones, including insulin, regulate enzyme activity. This chapter first reviews the current information regarding the complexities of the overall regulation of ACC activity and then focuses on the specific issue of acute regulation by hormones.

Keywords

Fatty Acid Synthesis Casein Kinase Fatty Acid Synthetase Acute Regulation Insulin Exposure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Lee A. Witters
    • 1
    • 2
  1. 1.Diabetes Unit and Medical ServicesMassachusetts General HospitalUSA
  2. 2.Department of MedicineHarvard Medical SchoolBostonUSA

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