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Role of Phosphorylation in the Regulation of Acetyl CoA Carboxylase Activity

  • Roger W. Brownsey
  • Richard M. Denton

Abstract

Insulin increases the rate of fatty acid synthesis in white fat cells,(1–3) brown fat cells,(4) liver cells,(5–8) and the lactating mammary glane(9,10) within a few minutes. Proportionally, the most impressive effects of insulin appear to occur in white and brown fat cells. In contrast, at least in white adipose tissue and liver, hormones that increase the concentration of cyclic adenosine monophosphate (cAMP) result in inhibition of fatty acid synthesis, esepcially in the presence of insulin.(3,11) To date, this has not been clearly demonstrated for brown fat and mammary tissue—probably because of the lack of adequate in vitro preparations of these tissues.

Keywords

Fatty Acid Synthesis Epididymal Adipose Tissue Adipose Tissue Enzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Roger W. Brownsey
    • 1
    • 2
  • Richard M. Denton
    • 1
  1. 1.Department of BiochemistryUniversity of Bristol Medical SchoolBristolEngland
  2. 2.Department of BiochemistryUniversity of British ColumbiaVancouverCanada

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