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Insulin Regulation of Glycogen Synthase in Rat Heart and Liver

  • Thomas B. MillerJr.

Abstract

This chapter touches on selected aspects of the regulation of glycogen synthase by insulin in rat heart and liver. An update on this area would seem timely due to reports during the past 10 years of reproducible insulin effects on glycogen synthase in perfused rat hearts and isolated rat liver preparations. While considerable work has been carried out in rat heart and liver preparations in vitro,the mechanistic knowledge of glycogen synthase regulation remains far behind that reported for rabbit skeletal muscle. The purpose of this chapter is to attempt to summarize recent knowledge related to the insulin regulation of rat heart and liver glycogen synthase and to present recent data pertinent to insulin action from our laboratory.

Keywords

Rabbit Skeletal Muscle Insulin Effect Glucose Incorporation Insulin Regulation Phosphorylase Phosphatase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Williamson, J.R., and Krebs, H.A., 1961, Biochem. J. 80: 540–551.PubMedGoogle Scholar
  2. 2.
    Williams, B.J., and Mayer, S.E., 1966, Mol. Pharmacol. 2: 454–464.PubMedGoogle Scholar
  3. 3.
    Huijing, F., Nuttall, F.Q., Villar-Palasi, C., and Lamer, J., 1969, Biochim. Biophys. Acta 177: 204–212.PubMedCrossRefGoogle Scholar
  4. 4.
    Sacristan, A., and Rosell-Perez, M., 1971, Rev. Esp. Fisiol. 27: 331–342.PubMedGoogle Scholar
  5. 5.
    Nuttall, F.Q., Gannon, M.C., and Bergstrom, W.J., 1975, Am. J. Physiol. 228: 1815–1820.Google Scholar
  6. 6.
    Nuttall, F.Q., Gannon, M.C., Corbett, V.A., and Wheeler, M.P., 1976, J. Biol. Chem. 251: 6724–6729.Google Scholar
  7. 7.
    Adolfsson, S., Isaksson, O., and Hjalmarson, A., 1972, Biochim. Biophys. Acta 279: 146–156.PubMedCrossRefGoogle Scholar
  8. 8.
    Miller, T.B., Jr., 1978, J. Biol. Chem. 253: 5389–5394.PubMedGoogle Scholar
  9. 9.
    Ramachandran, C., Angelos, K.L., and Walsh, D.A., 1982, J. Biol. Chem. 257: 1448–1457.PubMedGoogle Scholar
  10. 10.
    Ramachandran, C., Angelos, K.L., Sivaramakrishnan, S., and Walsh, D.A., 1983, Fed. Proc. 42: 9–13.PubMedGoogle Scholar
  11. 11.
    Miller, T.B., Jr., 1983, Am. J. Physiol. 245: E379 — E383.Google Scholar
  12. 12.
    McCullough, T.E., and Walsh, D.A., 1979, J. Biol. Chem. 254: 7336–7344.PubMedGoogle Scholar
  13. 13.
    Keely, S.L., Corbin, J.D., and Park, C.R., 1975, J. Biol. Chem. 250: 4832–4840.PubMedGoogle Scholar
  14. 14.
    Schlender, K.K., and Reimann, E.M., 1977, J. Biol. Chem. 252: 2384–2389.PubMedGoogle Scholar
  15. 15.
    Parker, P.J., Caudwell, F.B., and Cohen, P., 1983, Eur. J. Biochem. 130: 227–234.PubMedCrossRefGoogle Scholar
  16. 16.
    Das, I., 1973, Can. J. Biochem. 51: 637–641.PubMedGoogle Scholar
  17. 17.
    Lee, E.Y.C., Silberman, S.R., Ganapathi, M.K., Petrov c, S., and Paris, H., 1980, Adv. Cyclic Nucleotide Res. 13: 95–131.PubMedGoogle Scholar
  18. 18.
    Li, H.-C., 1982, Curr. Top. Cell. Regul. 20: 129–174.Google Scholar
  19. 19.
    Kinohara, N., Usui, H., Imazu, M., Imaoka, T., and Takeda, M., 1982, J. Biochem., 91: 177–190.PubMedGoogle Scholar
  20. 20.
    Yang, S-D., Vandenheede, J.R., Goris, J., and Merlevede, W., 1980, FEBS Lett. 111: 201–204.PubMedCrossRefGoogle Scholar
  21. 21.
    Lau, K-H.W., Chen, I-LG., and Thomas, J.A., 1982, Mol. Cell. Biochem. 44: 149–159.PubMedCrossRefGoogle Scholar
  22. 22.
    Miller, T.B., Jr., Praderio, M., Wolleben, C., and Bullman, Jr., 1981, J. Biol. Chem. 256: 1748–1753.PubMedGoogle Scholar
  23. 23.
    Lamer, J., Villar-Palasi, C., and Brown, N.E., 1969, Biochim. Biophys. Acta 178: 470–479.Google Scholar
  24. 24.
    Steiner, D.F., and Williams, R.H., 1959, J. Biol. Chem. 234: 1342–1349.PubMedGoogle Scholar
  25. 25.
    Steiner, D.F., Rauda, V., and Williams, R.H., 1961, J. Biol. Chem. 236: 299–304.Google Scholar
  26. 26.
    Kreutner, W., and Goldberg, N.D., 1967, Proc. Natl. Acad. Sci. USA 58:1515-1519.Google Scholar
  27. 27.
    Friedmann, B., Goodman, E.H., Jr., and Weinhouse, S., 1967, Endocrinology 81: 486–496.PubMedCrossRefGoogle Scholar
  28. 28.
    Gold, A.H., 1970, J. Biol. Chem. 245: 903–905.PubMedGoogle Scholar
  29. 29.
    Blatt, L.M., and Kim, K-H., 1971, J. Biol. Chem. 246: 7256–7264.PubMedGoogle Scholar
  30. 30.
    Miller, T.B., Jr., and Larner, J., 1973, J. Biol. Chem. 248: 3483–3488.PubMedGoogle Scholar
  31. 31.
    Mondon, C.E., and Burton, S.D., 1971, Am. J. Physiol. 220: 724–734.PubMedGoogle Scholar
  32. 32.
    Hostmark, A.T., 1973, Acta Physiol. Scand. 88: 248–255.PubMedCrossRefGoogle Scholar
  33. 33.
    Davidson, M.B., and Berliner, J.A., 1974, Am. J. Physiol. 227: 79–87.PubMedGoogle Scholar
  34. 34.
    Johnson, M.E.M., Das, N.M., Butcher, F.R., and Fain, J.N., 1972, J. Biol. Chem. 247: 3229–3235.PubMedGoogle Scholar
  35. 35.
    Wagle, S.R., Ingebretsen, W.R., and Sampson, L., 1973, Biochem. Biophys. Res. Commun. 53: 937–943.CrossRefGoogle Scholar
  36. 36.
    Seglen, P.O., 1973, FEBS Lett. 30: 25–28.PubMedCrossRefGoogle Scholar
  37. 37.
    Akpan, J.O., Gardner, R. and Wagle, S.R., 1974, Biochem. Biophys. Res. Commun. 61: 222–229.CrossRefGoogle Scholar
  38. 38.
    Witters, L.A., Alberico, L., and Avruch, J., 1976, Biochem. Biophys. Res. Commun. 69: 997–1003.CrossRefGoogle Scholar
  39. 39.
    Witters, L.A., and Avruch, J., 1978, Biochemistry 17: 406–410.PubMedCrossRefGoogle Scholar
  40. 40.
    Baldwin, D., Jr., Terris, S., and Steiner, D.F., 1980, J. Biol. Chem. 255: 4028–4034.PubMedGoogle Scholar
  41. 41.
    Beynen, A.C., and Geelen, M.J.H., 1981, Indian J. Exp. Biol. 19 :46–48.Google Scholar
  42. 42.
    Beynen, A.C., and Geelen, M.J.H., 1981, Horm. Metab. Res. 13:376-378.Google Scholar
  43. 43.
    Ciudad, C.J., Bosch, F., and Guinovart, J., 1981, FEBS Lett. 129: 123–126.PubMedCrossRefGoogle Scholar
  44. 44.
    Nyfeler, F., Fasel, P., and Walter, P., 1981, Biochim. Biophys. Acta 675: 17–23.PubMedCrossRefGoogle Scholar
  45. 45.
    Venkatesan, N., and Davidson, M.B., 1983, Life Sci. 32: 467–474.PubMedCrossRefGoogle Scholar
  46. 46.
    Storer, G.B., Trimble, R.P., and Topping, D.L., 1980, Biochem. J. 192: 219–222.PubMedGoogle Scholar
  47. 47.
    Storer, G.B., Topping, D.L., and Trimble, R.P., 1981, FEBS Lett. 136: 135–137.PubMedCrossRefGoogle Scholar
  48. 48.
    Plas, C., Menuelle, P., Moncany, M.L.J., and Fulchignoni-Lataud, M.C., 1979, Diabetes 28: 705–712.PubMedGoogle Scholar
  49. 49.
    Schudt, C., 1980, Biochim. Biophys. Acta 629: 499–509.CrossRefGoogle Scholar
  50. 50.
    Menuelle, P., and Plas, C., 1981, Diabetologia 20: 647–653.PubMedCrossRefGoogle Scholar
  51. 51.
    Plas, C., and Desbriquois, B., 1982, Biochem. J. 202: 333–341.PubMedGoogle Scholar
  52. 52.
    Reed, G.B., 1983, Exp. Mol. Pathol. 38:183–192.Google Scholar
  53. 53.
    Jett, M.F., and Soderling, T.R., 1979, J. Biol. Chem. 254: 6739–6745.PubMedGoogle Scholar
  54. 54.
    Guinovart, J.J., Salavert, A., Massaque, J., Ciudad, C.J., Salsas, E., and Itarte, E., 1979, FEBS Lett. 106: 284–288.PubMedCrossRefGoogle Scholar
  55. 55.
    Dopere, F., Vanstapel, F., and Stalmans, W., 1980, Eur. J. Biochem. 104: 137–146.PubMedCrossRefGoogle Scholar
  56. 56.
    Hiraga, A., Kikuchi, K., Tamura, S., and Tsuiki, S., 1981, Eur. J. Biochem. 119: 503–510.PubMedCrossRefGoogle Scholar
  57. 57.
    Bosch, F., Ciudad, C.J., and Guinovart, J., 1983, FEBS Lett. 151: 76–78.PubMedCrossRefGoogle Scholar
  58. 58.
    Akatsuka, A., Singh, T.J., and Huang, K-P., 1983, Arch. Biochem. Biophys. 220: 426–434.PubMedCrossRefGoogle Scholar
  59. 59.
    Huang, K-P., Akatsuka, A., Singh, T.J., and Blake, K.R., 1983, J. Biol. Chem. 258: 7094–7101.PubMedGoogle Scholar
  60. 60.
    Van de Werbe, G., Hue, L., and Hers, H.G., 1977, Biochem. J. 162:135–14 2.Google Scholar
  61. 61.
    Massague, J., and Guinovart, J.J., 1977, FEBS Lett. 82: 317–320.PubMedCrossRefGoogle Scholar
  62. 62.
    Gilboe, D.P., and Nuttall, F.Q., 1978, J. Biol. Chem. 253: 4078–4081.PubMedGoogle Scholar
  63. 63.
    Miller, T.B., Jr., Garnache, A., and Vicalvi, J.J., Jr., 1981, J. Biol. Chem. 256:2851–2855.Google Scholar
  64. 64.
    Mor, M.A., Vila, J., Ciudad, C.J., and Guinovart, J.J., 1981, FEBS Lett. 136: 131–134.PubMedCrossRefGoogle Scholar
  65. 65.
    Wasner, H.K., 1981, FEBS Lett. 133: 260–264.PubMedCrossRefGoogle Scholar
  66. 66.
    Berry, M.N., and Friend, D.S., 1969, J. Cell. Biol. 43: 506–520.PubMedCrossRefGoogle Scholar
  67. 67.
    Kochan, R.G., Lamb, D.R., Reimann, E.R., and Schlender, K.K., 1981, Am. J. Physiol. 240: E197 - E202.Google Scholar
  68. 68.
    Soderling, T.R., and Khatra, B.S., 1982, Calcium and Cell Function (W.Y. Cheung, ed.), Vol. III, pp. 189–221, Academic Press, New York.Google Scholar
  69. 69.
    Miller, T.B., Jr., Hazen, R., and Larner, J., 1973, Biochem. Biophys. Res. Commun. 53: 466–474.PubMedCrossRefGoogle Scholar
  70. 70.
    Whitton, P.D., and Hems, D.A., 1975, Biochem. J. 150: 153–165.PubMedGoogle Scholar
  71. 71.
    Miller, T.B., Jr., 1978, Am. J. Physiol. 234: E13 - E19.PubMedGoogle Scholar
  72. 72.
    Miller, T.B., Jr., 1979, Biochim. Biophys. Acta 583: 36–46.PubMedCrossRefGoogle Scholar
  73. 73.
    Haverstick, D.M., Dickemper, D., and Gold, A.H., 1979, Biochem. Biophys. Res. Commun. 87:177-183.PubMedCrossRefGoogle Scholar
  74. 74.
    Miller, T.B., Jr. Vicalvi, J.J., Jr., and Garnache, A.K., 1981, Am. J. Physiol. 240: E539 - E543.PubMedGoogle Scholar
  75. 75.
    Bollen, M., Hue, L., and Stalmans, W., 1983, Biochem. J. 210: 783–787.PubMedGoogle Scholar
  76. 76.
    Golden, S., Wals, P.A., Okajima, F., and Katz, J., 1979, Biochem. J. 182: 727–734.PubMedGoogle Scholar
  77. 77.
    Khandelwal, R.L., Zimman, S.M., and Zebrowski, E.J., 1977, Biochem. J. 168: 541–548.PubMedGoogle Scholar
  78. 78.
    Tan, A.W.H., and Nuttall, F.Q., 1976, Biochim. Biophys. Acta 445: 118–130.PubMedGoogle Scholar
  79. 79.
    Appel, M.C., Like, A.A., Rossini, A.A., Carp, D.B., and Miller, T.B., Jr., 1981, Am. J. Physiol. 240: E83 — E87.PubMedGoogle Scholar
  80. 80.
    Shenolikar, S., Strada, S.J., and Steiner, A.L., 1983, Fed. Proc. 42: 1801.Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Thomas B. MillerJr.
    • 1
  1. 1.The Department of BiochemistryUniversity of Massachusetts Medical SchoolWorcesterUSA

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