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Skeletal Muscle Glycogen Synthase: Hormonal Regulation

  • Thomas R. Soderling
  • Virender S. Sheorain

Abstract

Studies by Earner and associates(1,2) during the early 1960s established the hormonal responsiveness of glycogen synthase in skeletal muscle and other tissues. Epinephrine treatment of rat diaphragm results in inactivation of glycogen synthase whereas insulin promotes activation of the enzyme. Since similar kinetic effects on glycogen synthase can be obtained in muscle extracts by conditions that favor protein phosphorylation-dephosphorylation, this was postulated to be the molecular mechanism underlying the hormonal regulation.

Keywords

Phosphorylation Site Insulin Therapy Hormonal Regulation Phosphate Content Rabbit Skeletal Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Craig, J.W., and Lamer, J., 1964, Nature 202: 971–973.PubMedCrossRefGoogle Scholar
  2. 2.
    Craig, J.W., Rall, T.W., and Lamer, J., 1969, Biochim. Biophys. Acta 177: 213–219.PubMedCrossRefGoogle Scholar
  3. 3.
    Picton, C., Aitken, A., Bilham, T., and Cohen, P., 1982, Eur. J. Biochem. 124: 37–45.PubMedCrossRefGoogle Scholar
  4. 4.
    Juhl, H., Sheorain, V.S., Schworer, C.M., Jett, M.F., and Soderling, T.R., 1983, Arch. Biochem. Biophys. 222: 518–526.PubMedCrossRefGoogle Scholar
  5. 5.
    Soderling, T.R., and Khatra, B.S., in: Calcium and Cell Function,Vol. 3 (W.Y. Cheung, ed.), pp. 189–221, Academic Press, New York.Google Scholar
  6. 6.
    Roach, P.J., 1981, Curr. Top. Cell. Regul. 20: 45–104.PubMedGoogle Scholar
  7. 7.
    DePaoli-Roach, A.A., Ahmad, Z., and Roach, P.J., 1981, J. Biol. Chem. 256: 8955–8962.PubMedGoogle Scholar
  8. 8.
    Picton, C., Woodgett, J., Hemmings, B., and Cohen, P., 1982, FEBS Lett. 150: 191–196.PubMedCrossRefGoogle Scholar
  9. 9.
    Sheorain, V.S., Khatra, B.S., and Soderling, T.R., 1982, J. Biol. Chem. 257: 3462–3470.PubMedGoogle Scholar
  10. 10.
    Parker, P.J., Embi, N., Caudwell, F.B., and Cohen, P., 1982, Eur. J. Biochem. 124: 47–55.PubMedCrossRefGoogle Scholar
  11. 11.
    Parker, P.J., Caudwell, F.B., and Cohen, P., 1983, Eur. J. Biochem. 130: 227–234.PubMedCrossRefGoogle Scholar
  12. 12.
    Chiasson, J.L., Aylward, J.H., Shikama, H., and Exton, J.H., 1981, FEBS Lett. 127: 97–100.PubMedCrossRefGoogle Scholar
  13. 13.
    Uhing, R.J., Shikama, H., and Exton, J.H., 1981, FEBS Lett. 134: 185–188.PubMedCrossRefGoogle Scholar
  14. 14.
    Takeda, Y., and Lamer, J., 1975, J. Biol. Chem. 250: 8951–8956.PubMedGoogle Scholar
  15. 15.
    Soderling, T.R., 1976, J. Biol. Chem. 251: 4359–4364.PubMedGoogle Scholar
  16. 16.
    Soderling, T.R., Jett, M.F., Hutson, N.J., and Khatra, B.S., 1977, J. Biol. Chem. 252: 7517–7524.PubMedGoogle Scholar
  17. 17.
    Soderling, T.R., Srivastava, A.K., Bass, M.A., and Khatra, B.S., 1979, Proc. Natl. Acad. Sci. USA 76: 2536–2540.PubMedCrossRefGoogle Scholar
  18. 18.
    Soderling, T.R., 1979, Mol. Cell. Endocrinol. 16: 157–179.PubMedCrossRefGoogle Scholar
  19. 19.
    Soderling, T.R., and Walsh, K., 1982, J. Chromatogr. 253: 243–251.CrossRefGoogle Scholar
  20. 20.
    Komuniecki, P.R., Kochan, R.G., Schlender, K.K., and Reimann, E.M., 1982, Mol. Cell. Biochem. 48: 129–134.PubMedCrossRefGoogle Scholar
  21. 21.
    Foulkes, J.G., and Cohen, P., 1979, Eur. J. Biochem. 97: 251–256.PubMedCrossRefGoogle Scholar
  22. 22.
    Khatra, B.S., Chiasson, J.L., Shikama, H., Exton, J.H., and Soderling, T.R., 1980, FEBS Lett. 114: 253–256.PubMedCrossRefGoogle Scholar
  23. 23.
    Khatra, B.S., and Soderling, T.R., 1983, Arch. Biochem. Biophys. 227: 39–51.PubMedCrossRefGoogle Scholar
  24. 24.
    Gold, A.H., 1970, J. Biol. Chem. 245: 903–906.PubMedGoogle Scholar
  25. 25.
    Miller, T.B., 1978, J. Biol. Chem. 253: 5389–5394.PubMedGoogle Scholar
  26. 26.
    Perisic, O., and Traugh, J.A., 1983, J. Biol. Chem. 256: 9589–9592.Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Thomas R. Soderling
    • 1
  • Virender S. Sheorain
    • 1
  1. 1.Howard Hughes Medical Institute and Department of PhysiologyVanderbilt Medical CenterNashvilleUSA

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