Skeletal Muscle Glycogen Synthase: Hormonal Regulation

  • Thomas R. Soderling
  • Virender S. Sheorain


Studies by Earner and associates(1,2) during the early 1960s established the hormonal responsiveness of glycogen synthase in skeletal muscle and other tissues. Epinephrine treatment of rat diaphragm results in inactivation of glycogen synthase whereas insulin promotes activation of the enzyme. Since similar kinetic effects on glycogen synthase can be obtained in muscle extracts by conditions that favor protein phosphorylation-dephosphorylation, this was postulated to be the molecular mechanism underlying the hormonal regulation.


Phosphorylation Site Insulin Therapy Hormonal Regulation Phosphate Content Rabbit Skeletal Muscle 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Thomas R. Soderling
    • 1
  • Virender S. Sheorain
    • 1
  1. 1.Howard Hughes Medical Institute and Department of PhysiologyVanderbilt Medical CenterNashvilleUSA

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