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Intracellular Mediators of Insulin Action

  • Leonard Jarett
  • S. Lance Macaulay
  • Janice C. Parker
  • Kathleen L. Kelly
  • Frederick L. Kiechle

Abstract

Insulin is the key anabolic hormone regulating the metabolism of carbohydrates, lipids, and proteins, especially in muscle, liver, and adipose tissue. This regulation is brought about by changes in membrane events that occur within seconds, in various intracellular processes that occur within minutes, and in nuclear functions involved in growth that occur within hours. The initial event responsible for these metabolic alterations results from the interaction of insulin with its receptor on the plasma membrane of responsive cells. Yet, the molecular events that occur subsequent to the hormone—receptor interaction and which lead to the metabolic alterations are unknown. A number of compounds, including cyclic nucleotides, calcium, a fragment of insulin, and hydrogen peroxide, have been suggested to be the second messenger or intracellular mediator of insulin action. None of these candidates has been demonstrated to mimic all the metabolic actions of insulin and to work in vivo as well as in vitro. Therefore, they are unlikely to be insulin mediators. This subject has been reviewed extensively in recent years.(1–8)

Keywords

Insulin Action Liver Plasma Membrane Intracellular Mediator cAMP Phosphodiesterase Plasma Membrane Preparation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Leonard Jarett
    • 1
  • S. Lance Macaulay
    • 1
  • Janice C. Parker
    • 1
  • Kathleen L. Kelly
    • 1
  • Frederick L. Kiechle
    • 2
  1. 1.Department of Pathology and Laboratory MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.Department of Clinical PathologyWilliam Beaumont HospitalRoyal OakUSA

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