Genetic Control of the Connectivity and Excitability of Cerebellar Purkinje Cells in Rodents

  • Francis Crepel
  • Jean-Luc Dupont
  • Robert Gardette
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 181)


The development of synaptic contacts between nerve cells and of the excitability of neuronal membranes are two important steps in the building of the nervous system. Hughes (1968a,b) was the first to state that during the normal course of development, connections are initially more diffuse than in the adult, i.e. the adult-type neuronal circuits derive not only from an increase in the total number of synaptic contacts, but also from the elimination of irrelevant connections. Indeed, this idea was not really new since at the turn of the century, Cajal (1911) had already described the presence of transient axonal projections in the central nervous system of mammals at early developmental stages.


Purkinje Cell Cerebellar Cortex Parallel Fibre Climbing Fibre Cerebellar Purkinje Cell 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Francis Crepel
    • 1
  • Jean-Luc Dupont
    • 1
  • Robert Gardette
    • 1
  1. 1.INSERM U97ParisFrance

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