Novel Insulin-Related Sequences in Fetal Brain

  • Lydia Villa-Komaroff
  • Antonio Gonzalez
  • Song Hou-Yan
  • Bruce Wentworth
  • Paul Dobner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 181)


An examination of the literature leaves no doubt that there is a moiety which cross-reacts with anti-insulin antibodies in the central and peripheral nervous systems. However, there is considerable doubt as to how much of this material there is, where exactly it resides, where it originates and what role it plays. In this chapter, we will review the evidence for the presence and synthesis of insulin or insulin-like peptides in the nervous system and we will describe how we are using recombinant DNA technology to identify and characterize RNA sequences homologous, but not identical, to sequences encoding insulin. (We will not deal with immunoreactive insulin in invertebrates [for review, see Le Roith et al].)


Insulin Receptor Cerebral Spinal Fluid Phage Particle Immunoreactive Insulin Human Fetal Brain 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Lydia Villa-Komaroff
    • 1
  • Antonio Gonzalez
    • 1
  • Song Hou-Yan
    • 1
  • Bruce Wentworth
    • 1
  • Paul Dobner
    • 1
  1. 1.Molecular Genetics and MicrobiologyUniversity of Massachusetts Medical CenterWorcesterUSA

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