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Regulation of Synapse Formation by Cyclic AMP

  • M. Nirenberg
  • K. Krueger
  • A. Rotter
  • S. Wilson
  • H. Higashida
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 181)

Abstract

One neuroblastoma and four hybrid cell lines were obtained which formed numerous synapses with cultured striated muscle cells. Many other neuroblastoma or somatic cell hybrids were found which synthesized acetylcholine, but which lacked one or more properties needed to form functional synapses. The following kinds of clonally inherited synaptic defects were identified in these cell lines: alterations in voltage-sensitive Ca2+ channel activity, large dense-core vesicles, depolarization-dependent acetylcholine secretion, and the lack of functional protein synthesized and released into the medium by the neural cells (which normally Increases aggregation of nicotinic acetylcholine receptors on myotube plasma membranes).

Keywords

Channel Activity Nicotinic Acetylcholine Receptor Synapse Formation Somatic Cell Hybrid Cyclic Nucleotide Phosphodiesterase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • M. Nirenberg
    • 1
  • K. Krueger
    • 1
  • A. Rotter
    • 1
  • S. Wilson
    • 1
  • H. Higashida
    • 1
  1. 1.Laboratory of Biochemical Genetics, National Heart, Lung and Blood InstituteNational Institutes of HealthBethesdaUSA

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