Neuron-Glia Interactions and Glial Enzyme Expression in Mouse Cerebellum

  • Marilyn Fisher
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 181)


One of the major goals that developmental neurobiologists share with those studying other developing systems is understanding the role of cell interactions during morphogenesis and cell differentiation. A variety of significant interactions between neighboring cells occur during the formation of a normal adult nervous system. In vertebrate embryos these interactions begin with the induction of the neural epithelium by the underlying notochord. Similar interactions are involved in the morphogenesis and differentiation of auditory, lens and olfactory placodes. Slightly later during brain development different types of cell interactions come into play. For example, radial glia serve as guides physically directing the migration of neurons, and appropriate interactions (i.e. synapse formation) among certain developing neuron populations are believed vital to the ultimate survival of those neurons. Although these and other examples of cellular interactions are widely accepted as important forces during embryonic development, the mechanisms through which they operate have proven to be elusive.


Purkinje Cell Molecular Layer Granule Cell Layer GPDH Activity Bergmann Glia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Aguayo, A. J., Charron, L., and Bray, G. M., 1976a, Potential of Schwann cells from unmyelinated nerves to produce myelin: A quantitative ultrastructural and radiographic study, J. Neurocytol., 5:565.CrossRefGoogle Scholar
  2. Aguayo, A. J., Epps, J., Charron, L., and Bray, G. M., 1976b, Multipotentiality of Schwann cells in cross-anastomosed and grafted unmyelinated nerves. Quantitative microscopy and radioautography, Brain Res., 104:1.CrossRefGoogle Scholar
  3. Bignami, A., and Dahl, D., 1974, The development of Bergmann glia in mutant mice with cerebellar malformation: reeler, staggerer and weaver. Immunofluorescence study with antibodies to the glial fibrillary acidic protein, J. Comp. Neurol., 155:219.PubMedCrossRefGoogle Scholar
  4. Bradley, P., and Berry, M., 1978, Purkinje cell dendritic tree in mutant mouse cerebellum. A quantitative Golgi study of weaver and staggerer mice, Brain Res., 142:135.PubMedCrossRefGoogle Scholar
  5. Caddy, K. W. T., and Biscoe, T. J., 1979, Structural and quantitative studies on the normal C3H and Lurcher mutant mouse, Philos. Trans. Roy. Soc. London, 287:167.CrossRefGoogle Scholar
  6. Chan, A. K., and Thompson, E. A., 1981, Appearance of a second form of hepatic glycerol-3-phosphate dehydrogenase during neonatal development in the mouse, Arch. Biochem. Biophys., 207:96.PubMedCrossRefGoogle Scholar
  7. de Vellis, J., McGinnis, J. F., Breen, G. A. M., Leveille, P., Bennett, K., and McCarthy, K., 1977, Hormonal Effects on differentiation in neural cultures, in: “Cell Tissue and Organ cultures in Neurobiology,” S. Federoff and L. Hertz, eds., Academic Press, New York.Google Scholar
  8. Fisher, M., 1984, Neuronal influence on glial enzyme expression: Evidence from mutant mouse cerebella, Submitted.Google Scholar
  9. Fisher, M., Gapp, D. A., and Kozak, L. P., 1981, Immunohistochemical localization of sn-glycerol-3-phosphate dehydrogenase in Bergmann glia and oligodendroglia in the mouse cerebellum, Dev. Brain Res., 1:341.CrossRefGoogle Scholar
  10. Kozak, L. P., 1972, Genetic control of a-glycerol phosphate dehydrogenase in mouse brain, Proc. Natl. Acad. Sci. USA, 69:3170.PubMedCrossRefGoogle Scholar
  11. Kozak, L. P., 1977, The transition from embryonic to adult isozyme expression in reaggregating cell cultures of mouse brain, Dev. Biol., 55:160.PubMedCrossRefGoogle Scholar
  12. Kozak, L. P., and Birkenmeier, E. H., 1983, Mouse sn-glycerol-3-phosphate dehydrogenase: Molecular cloning and genetic mapping of a cDNA sequence, Proc. Natl. Acad. Sci. USA, 80:3020.PubMedCrossRefGoogle Scholar
  13. Kozak, L. P., Burkart, D. L., and Hjorth, J. P., 1982, Unlinked structural genes for the developmentally regulated isozymes of sn-glycerol-3-phosphate dehydrogenase in mice, Dev. Genet., 3:1.CrossRefGoogle Scholar
  14. Kozak, L. P., and Erdelsky, K. J., 1975, The genetics and developmental regulation of L-glycerol-3-phosphate dehydrogenase, J. Cell. Physiol., 85:437.PubMedCrossRefGoogle Scholar
  15. Kozak, L. P., and Jensen, J. T., 1974, Genetic and developmental control of multiple forms of L-glycerol-3-phosphate dehydrogenase, J. Biol. Chem., 249:7775.PubMedGoogle Scholar
  16. Kozak, L. P., and Ratner, P. L., 1980, Genetic regulation of translatable mRNA levels of mouse sn-g1ycero1–3-phosphate dehydrogenase during development of the cerebellum, J. Biol. Chem., 255:7589.PubMedGoogle Scholar
  17. Lin, E. C. C., 1977, Glycerol utilization and its regulation in mammals, Ann. Rev. Biochem., 46:765.PubMedCrossRefGoogle Scholar
  18. Linser, P., and Moscona, A. A., 1979, Induction of glutamine synthetase in embryonic neural retina: Localization in Muller fibers and dependence on cell interactions, Proc. Natl. Acad. Sci. USA, 76:6476.PubMedCrossRefGoogle Scholar
  19. Mullen, R. J., 1977, Site of pcd gene action and Purkinje cell mosaicism in cerebella of chimaeric mice, Nature, 270:245.PubMedCrossRefGoogle Scholar
  20. Mullen, R. J., Eicher, E. M., and Sidman, R. L., 1976, Purkinje cell degeneration, a new neurological mutation in the mouse, Proc. Natl. Acad. Sci. USA, 73:208.PubMedCrossRefGoogle Scholar
  21. Palay, S. L., and Chan-Palay, V., 1974, “Cerebellar Cortex,” Springer-Verlag, New York.CrossRefGoogle Scholar
  22. Rakic, P., and Sidman, R. L., 1973, Weaver mutant mouse cerebellum: Defective neuronal migration secondary to abnormality of Bergmann glia, Proc. Natl. Acad. Sci USA, 70:240.PubMedCrossRefGoogle Scholar
  23. Sidman, R. L., 1968, Development of interneuronal connections in brains of mutant mice, in: “Physiological and Biochemical Aspects of Nervous Integration,” F. D. Carlson, ed., Prentice-Hall Inc., Englewood Cliffs, N. J.Google Scholar
  24. Sidman, R. L., and Green, M. C., 1970, “Nervous”, a new mutation with cerebellar disease, in: “Les Mutants Pathologiques chez L’animal,” M. Sabourdy, ed., Centre National de La Recherche Scientifique, Paris.Google Scholar
  25. Sotelo, C., and Changeux, J. P., 1974, Bergmann fibers and granular cell migration in the cerebellum of homozygous weaver mutant mouse, Brain Res., 77:484.PubMedCrossRefGoogle Scholar
  26. Wetts, R., and Herrup, K., 1982, Interaction of granule, Purkinje and inferior olivary neurons in Lurcher chimaeric mice. I. Qualitative studies, J. Embryo1. Exp. Morph., 68:87.Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Marilyn Fisher
    • 1
  1. 1.Anatomy DepartmentUniversity of Utah School of MedicineSalt Lake CityUSA

Personalised recommendations