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Neuron-Glia Interactions and Glial Enzyme Expression in Mouse Cerebellum

  • Marilyn Fisher
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 181)

Abstract

One of the major goals that developmental neurobiologists share with those studying other developing systems is understanding the role of cell interactions during morphogenesis and cell differentiation. A variety of significant interactions between neighboring cells occur during the formation of a normal adult nervous system. In vertebrate embryos these interactions begin with the induction of the neural epithelium by the underlying notochord. Similar interactions are involved in the morphogenesis and differentiation of auditory, lens and olfactory placodes. Slightly later during brain development different types of cell interactions come into play. For example, radial glia serve as guides physically directing the migration of neurons, and appropriate interactions (i.e. synapse formation) among certain developing neuron populations are believed vital to the ultimate survival of those neurons. Although these and other examples of cellular interactions are widely accepted as important forces during embryonic development, the mechanisms through which they operate have proven to be elusive.

Keywords

Purkinje Cell Molecular Layer Granule Cell Layer GPDH Activity Bergmann Glia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Marilyn Fisher
    • 1
  1. 1.Anatomy DepartmentUniversity of Utah School of MedicineSalt Lake CityUSA

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