Neuron-Glia Interactions and Glial Enzyme Expression in Mouse Cerebellum
One of the major goals that developmental neurobiologists share with those studying other developing systems is understanding the role of cell interactions during morphogenesis and cell differentiation. A variety of significant interactions between neighboring cells occur during the formation of a normal adult nervous system. In vertebrate embryos these interactions begin with the induction of the neural epithelium by the underlying notochord. Similar interactions are involved in the morphogenesis and differentiation of auditory, lens and olfactory placodes. Slightly later during brain development different types of cell interactions come into play. For example, radial glia serve as guides physically directing the migration of neurons, and appropriate interactions (i.e. synapse formation) among certain developing neuron populations are believed vital to the ultimate survival of those neurons. Although these and other examples of cellular interactions are widely accepted as important forces during embryonic development, the mechanisms through which they operate have proven to be elusive.
KeywordsPurkinje Cell Molecular Layer Granule Cell Layer GPDH Activity Bergmann Glia
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- de Vellis, J., McGinnis, J. F., Breen, G. A. M., Leveille, P., Bennett, K., and McCarthy, K., 1977, Hormonal Effects on differentiation in neural cultures, in: “Cell Tissue and Organ cultures in Neurobiology,” S. Federoff and L. Hertz, eds., Academic Press, New York.Google Scholar
- Fisher, M., 1984, Neuronal influence on glial enzyme expression: Evidence from mutant mouse cerebella, Submitted.Google Scholar
- Sidman, R. L., 1968, Development of interneuronal connections in brains of mutant mice, in: “Physiological and Biochemical Aspects of Nervous Integration,” F. D. Carlson, ed., Prentice-Hall Inc., Englewood Cliffs, N. J.Google Scholar
- Sidman, R. L., and Green, M. C., 1970, “Nervous”, a new mutation with cerebellar disease, in: “Les Mutants Pathologiques chez L’animal,” M. Sabourdy, ed., Centre National de La Recherche Scientifique, Paris.Google Scholar
- Wetts, R., and Herrup, K., 1982, Interaction of granule, Purkinje and inferior olivary neurons in Lurcher chimaeric mice. I. Qualitative studies, J. Embryo1. Exp. Morph., 68:87.Google Scholar