The Influence of Neuronal-Glial Interactions on Glia-Specific Gene Expression in Embryonic Retina
The role of cell-cell interactions in morphogenesis and differentiation of neural cells and tissues has been increasingly the focus of considerable research activity (especially in recent years). One of the most popular model systems for investigating these problems is the embryonic neural retina. It is widely accepted that interactions between heterotypic cells in the retina influence various developmental processes (Moscona, 1974; Moscona & Linser, 1983). Our studies have addressed specifically the role of cell interactions in regulating the expression of developmentally programmed gene products. Since the avian retina is avascular, biochemical and other studies on this tissue are not complicated by the presence of non-neural cells. Also, since the avian retina contains only one kind of neuroglia, Muller cells (Cajal, 1973), it is possible to investigate the influence of retinal neurons on gene expressions in the glial cell compartment. In this paper, we review some of our observations concerning the role of neuron-glia interactions in regulating the expression of specific gene products which are sequestered in the glial compartment of the mature retina.
KeywordsGlutamine Synthetase Kainic Acid Glia Cell Neural Retina Muller Cell
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