The Mechanism of Binding of Neural Cell Adhesion Molecules
The morphology and cellular interconnections within the nervous system of higher organisms arise as a result of complex cell-cell interactions occurring throughout development. In order to identify the cell surface molecules mediating the adhesion that regulates many of these interactions, a variety of assays have been used and several molecules have been proposed to be involved in neural cell adhesion (Merrell et al., 1975; Hausman and Moscona, 1976; Urushihara et al., 1979; Marchase et al., 1981; Magnani et al., 1981; Grunwald et al., 1982; Roth and Pierce, 1982; Sadoul et al., 1983; Lindner et al., 1983). In our laboratory, an immunological approach devised by one of us (GME) led to the identification (Brackenbury et al., 1977; Thiery et al., 1977) and purification of a protein involved in calcium-independent neural cell adhesion which has been named the neural cell adhesion molecule or N-CAM. A number of other CAMs of different structure and specificity have since been identified (See Edelman, 1983, for a review).
KeywordsSialic Acid Retinal Cell Neural Cell Adhesion Molecule Sialic Acid Content Neurite Bundle
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