Molecular Biology of the Nerve Growth Cone: A Perspective
As so vividly described by Cajal, the nerve growth cone is the amoeboid, leading edge of the growing neurite. It occurs only during a narrow segment of the neuron’s life, during the time between terminal mitosis and synaptogenesis and, possibly in somewhat different form, during regeneration. As the growing, advancing tip, the nerve growth cone plays a crucial role in nervous system development. It is critical for the establishment of the neuron’s unusual geometry and high degree of polarity because it appears to be the main site of insertion of new plasmalemma1 components for surface expansion (Pfenninger and Maylié-Pfenninger, 1981b; Pfenninger and Johnson, 1983). Furthermore, the growth cone is the structure responsible for vectorial growth into the appropriate target area because it is capable of locomotion, pathfinding and Chemotaxis (see below). Last but not least, it is the structure which recognizes the target cell and triggers synaptogenesis.
KeywordsNerve Growth Factor Neuritic Growth Growth Cone Synaptic Terminal Nerve Growth Factor Receptor
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- Crews, F.T., Morita, Y., McGivney, A., Hirata, F., Siraganian, R.P., and Axelrod, J., 1981, IgE mediated histamine release in rat basophilic leukemia cells: Receptor activation, phospholipid methylation, Ca2+ flux and release of arachidonic acid, Arch. Biochem. Biophys., 212:561–571.PubMedCrossRefGoogle Scholar
- Ellis, L., Katz, R., and Pfenninger, K.H., 1983, Characterization of phosphoproteins of isolated nerve growth cone particles, J. Cell Biol., 97:242a.Google Scholar
- Ellis, L., Katz, F., and Pfenninger, K.H., 1984, Nerve growth cones isolated from fetal rat brain: III. cAMP-binding proteins and cAMP-dependent protein phosphorylation, in submission.Google Scholar
- Ellis, L., and Pfenninger, K.H., 1984, Nerve growth cones isolated from fetal rat brain: II. Polypeptides of growth cone membranes, in submission.Google Scholar
- Katz, F., Ellis, L., and Pfenninger, K.H., 1984, Nerve growth cones isolated from fetal rat brain: IV. Calcium-dependent protein phosphorylation, in submission.Google Scholar
- Llinas, R., and Sugimori, M., 1979, Calcium conductances in Purkinje cell dendrites: Their role in development and integration, in: “Development and Chemical Specificity of Neurons,” M. Cuenod, G.W. Kreutzberg and F.E. Bloom, eds., Progr. Brain Res., 51:323–334, Elsevier/North Holland Biomedical Press, Amsterdam.CrossRefGoogle Scholar
- McGivney, A., Crews, F.T., Hirata, F., Axelrod, J., and Siraganian, R.P., 1981, Rat basophilic leukemia cell lines defective in phospholipid methyltransferase enzymes, Ca2+ influx, and histamine release: Reconstitution by hybridization, Proc. Natl. Acad. Sci. USA, 78:6176–6180.PubMedCrossRefGoogle Scholar
- Ramón y Cajal, S., 1937, Recollections of my life, translated by E.H. Craigie, with the assistance of J. Cano, in: “Memoirs of the American Philosophical Society,” vol. VIII, part 1, pp. 368–869, The American Philosophical Society, Philadelphia.Google Scholar
- Simkowitz, P., and Pfenninger, K.H., 1983, Rapidly transported proteins of nerve growth cones and synaptic endings are markedly different, Soc. Neurosci. Abst., 9:1178.Google Scholar
- Small, R.K. and Pfenninger, K.H., 1984, Components of the plasma membrane of growing axons: I. Spatial distribution of intramembrane particles, J. Cell Biol., 98: in press.Google Scholar
- Theiler, R.F., and McClure, W.D., Rapid axoplasmic transport of proteins in regenerating sensory nerve fibers, J. Neurochem., 31:433–447.Google Scholar
- Wallis, I., Ellis, L., and Pfenninger, K.H., 1983, A neuronal polypeptide expressed during neurite formation, J. Cell Biol., 97:242a.Google Scholar