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Factors Influencing the Metabolic and Functional Alterations Induced by Ischemia and Reperfusion

  • R. Ferrari
  • F. Di Lisa
  • R. Raddino
  • C. Bigoli
  • S. Curello
  • C. Ceconi
  • A. Albertini
  • O. Visioli

Abstract

Myocardial ischemia describes a condition that exists when fractional uptake of oxygen in the heart is not sufficient to maintain the rate of cellular oxidation. This leads to an extremely complex situation which has been extensively studied in recent years. Part of this complexity is due to the fact that experimental myocardial ischemia results in a nonhomogeneous tissue damage which depends on the duration of the ischemic period, degree of coronary flow reduction and substrate availability.

Keywords

Coronary Flow Mitochondrial Calcium Ischemic Period Develop Pressure Moderate Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Waters, D.D., Da Luz, P., Wyatt, H.L., Swan, J.C., & Forrester, J.S. (1977): Am. J. Cardiol. 39: 537.PubMedCrossRefGoogle Scholar
  2. 2.
    Opie, L.H. (1930): Am. Heart J. 100: 355.CrossRefGoogle Scholar
  3. 3.
    Hearse, D.J., Opie, L.H., Katzeff, I.E., Lubbe, W.F., Van Der Welf, T.J., Persach, M., & Boulle, G. (1977): Am. J. Cardiol. 40: 176.CrossRefGoogle Scholar
  4. 4.
    Katz, A.M., & Messineo, F.C. (1981): Circ. Res. 48: 1.PubMedGoogle Scholar
  5. 5.
    Neely, J.R., & Feuvray, D. (1981): Am. J. Pathol. 102: 282.PubMedGoogle Scholar
  6. 6.
    Opie, L.H., & Bicknell, O.L. (1979): Cardiovasc. Res. 13: 693.PubMedCrossRefGoogle Scholar
  7. 7.
    Vik-Mo, H., & Mjos, O.D. (1983): In Myocardial Ischemia and Protection (ed) H. Refoum, P. Jynge, & O.P. Mjos, Churchill Livingstone, London, p. 35.Google Scholar
  8. 8.
    Liedtke, A.J. (1978): Circ. Res. 43: 652.PubMedGoogle Scholar
  9. 9.
    Lochner, A., Kotze, J.C.N., Benade, A.J.S., & Gevers, W. (1978): J. Mol. Cell. Cardiol. 10: 857.PubMedCrossRefGoogle Scholar
  10. 10.
    Feuvray, D., & Plovet, J. (1981): Circ. Res. 48: 740.PubMedGoogle Scholar
  11. 11.
    Langendorff, O. (1895): Pflugers Archiv. 61: 291.CrossRefGoogle Scholar
  12. 12.
    Krebs, H.A., & Henseleit, K. (1932): Hoppe-Seyler’s Zeit. fur Physiol. Chem. 210: 33.CrossRefGoogle Scholar
  13. 13.
    Ferrari, R., Williams, A., & Di Lisa, F. (1982): In Advances in Studies on Heart Metabolism (eds) C.M. Caldarera, & P. Harris, Clueb, Bologna, p. 245.Google Scholar
  14. 14.
    Oram, J., Benntch, S.L., & Neely, J.R. (1973): J. Biol. Chem. 248: 5299.PubMedGoogle Scholar
  15. 15.
    Ducombe, W.G. (1964): Clin. Chim. Acta 9:122.CrossRefGoogle Scholar
  16. 16.
    Nayler, W.G., Ferrari, R., & Williams, A. (1980): Am. J. Cardiol. 46: 242.PubMedCrossRefGoogle Scholar
  17. 17.
    Ferrari, R., Di Lisa, F., Raddino, R., & Visioli, O. (1982): J. Mol. Cell. Cardiol. 14: 737.PubMedCrossRefGoogle Scholar
  18. 18.
    Bradford, M. (1978): Anal. Biochem. 72: 248.CrossRefGoogle Scholar
  19. 19.
    Lamprecht, W., & Trautschold, E. (1974): In Methodes of Enzymatic Analysis (ed) H.U. Bergmeyer, Academic Press, New York, p. 2101.Google Scholar
  20. 20.
    Wollenberger, A., Ristau, O., & Scoffa, G. (1960): Pflugers Archiv. 270: 399.CrossRefGoogle Scholar
  21. 21.
    Oliver, I.T.A. (1955): Biochem. J. 61: 116.PubMedGoogle Scholar
  22. 22.
    Nayler, W.G., Poole-Wilson, P.A., & Williams, A. (1979): J. Mol. Cell. Cardiol. 11: 683.PubMedCrossRefGoogle Scholar
  23. 23.
    Watts, J.A., Charles, O.K., & Lanoue, K.F. (1980): Am. J. Physiol. 238: H909.PubMedGoogle Scholar
  24. 24.
    Jennings, R.B., & Reimer, K.A. (1981): Am. J. Pathol. 102: 241.PubMedGoogle Scholar
  25. 25.
    Langer, G.A. (1974): In The Mammalian Myocardium (eds) G.A. Langer & A.J. Brady, J. Wiley and Sons Inc., New York, p. 193.Google Scholar
  26. 26.
    Dobson, J.G., & Mayer, S.E. (1973): Circ. Res. 33: 412.PubMedGoogle Scholar
  27. 27.
    Berne, R.M., & Rubio, R. (1974): Circ. Res. 23: 109.Google Scholar
  28. 28.
    Wood, J.M., Hutchings, A.E., & Brachfeld, N. (1972): J. Mol. Cell. Cardiol. 4: 97.PubMedCrossRefGoogle Scholar
  29. 29.
    Larner, J. (1978): Circ. Res. 38 (Suppl. 1): 2.Google Scholar
  30. 30.
    Nayler, W.G. (1981): Am. J. Pathol. 102: 262.PubMedGoogle Scholar
  31. 31.
    Hearse, D.J., Garlick, P.B., & Humphrey, S.M. (1976): Am. J. Cardiol. 39: 286.Google Scholar
  32. 32.
    Rovetto, M.J., Lamberton, W.F., & Neely, J.R. (1975): Circ. Res. 37: 42.Google Scholar
  33. 33.
    Ferrari, R., Williams, A.J., & Nayler, W.G. (1979): J. Mol. Cell. Cardiol. 11: 13.Google Scholar
  34. 34.
    Ferrari, R., Di Lisa, F., Raddino, R., Curello, S., Ceconi, C., & Visioli, O. (1983): J. Mol. Cell. Cardiol. 15: 6.Google Scholar
  35. 35.
    Hearse, D.J. (1977): J. Mol. Cell. Cardiol. 9: 607.Google Scholar
  36. 36.
    Williams, A.J., Crie, J.S., & Ferrari, R. (1980): Circulation 62: 177.Google Scholar
  37. 37.
    Meerson, F.Z., Kagan, V.E., Yu, P., Kozlov, L.M., Belkina, U., & Arkhipenko, I. (1982): Basic Res. Cardiol. 17: 465.CrossRefGoogle Scholar
  38. 38.
    Nicholis, D., & Crompton, M. (1980): FEBS Lett. 11: 261.CrossRefGoogle Scholar
  39. 39.
    Lehninger, A.L. (1974): Circ. Res. 35: 83.PubMedGoogle Scholar
  40. 40.
    Neely, J.R., Whitmer, J.T., & Rovetto, M.Y. (1975): Circ. Res. 37: 733.PubMedGoogle Scholar
  41. 41.
    Smith, M.W., Collon, Y., Kaing, M., & Trump, B.F. (1980): Biochim. Biophys. Acta 618: 1992.Google Scholar
  42. 42.
    Henry, P.D., Schuchleid, R., Davis, J., Weiss, E.S., & Sobel, B.E. (1977): Am. J. Physiol. 233: H677.PubMedGoogle Scholar
  43. 43.
    Parr, D.R., Wimhurst, J.M., & Harris, E.J. (1973): Cardiovasc. Res. 9: 366.CrossRefGoogle Scholar
  44. 44.
    McCormarck, J.G., & Denton, R.M. (1980): Biochem. J. 190: 5.Google Scholar
  45. 45.
    Denton, R.M., McCormarck, J.G., & Edgell, N.J. (1980): Biochem. J. 190: 107.PubMedGoogle Scholar
  46. 46.
    Snug, A.L., Shrago, E., Bittar, V., Folts, J.D., & Koke, J.R. (1975): Am. J. Physiol. 228: 689.Google Scholar
  47. 47.
    Shrago, E., Shug, A.L., Sul, H., Bittar, V., & Folts, J.D. (1970): Circ. Res. 38: 1.Google Scholar
  48. 48.
    Whitmer, J.T., Wenger, J.I., Rovetto, M.J., & Neely, J.R. (1978): J. Biol. Chem. 253: 430.Google Scholar
  49. 49.
    Adams, R.J., Cohen, W., Gupte, S., Johnson, J.D., Wallik, E., Wang, T., & Schwartz, A. (1979): J. Biol. Chem. 254: 12404.PubMedGoogle Scholar
  50. 50.
    Messineo, F.C., Pinto, P.B., & Katz, A.M. (1980): J. Mol. Cell. Cardiol. 12: 725.PubMedCrossRefGoogle Scholar
  51. 51.
    Van der Vusse, G.J., Roemen, T.H.N., Prinzen, W.F., Comans, W.A., & Reneman, R.S. (1982): Circ. Res. 50: 538.PubMedGoogle Scholar
  52. 52.
    Jennings, R.B., Ganote, C.E. (1976): Circ. Res. 38: 80.Google Scholar
  53. 53.
    Idell-Wenger, J.A., & Neely, J.R. (1978): In Disturbances in lipid and lipoprotein metabolism (eds) J.M. Dietschy, A.M. Giotto, & J.A. Ontko, American Physiological Society, Baltimore.Google Scholar
  54. 54.
    Oliver, M.F., Kurier, V.A., & Greenwood, T.W. (1968): Lancet i: 710.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • R. Ferrari
    • 1
  • F. Di Lisa
    • 1
  • R. Raddino
    • 1
  • C. Bigoli
    • 1
  • S. Curello
    • 1
  • C. Ceconi
    • 1
  • A. Albertini
    • 1
  • O. Visioli
    • 1
  1. 1.School of MedicineUniversity of BresciaBresciaItaly

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