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Modulation of Membrane Function by Lipid Intermediates: A Possible Role in Myocardial Ischemia

  • J. M. J. Lamers
  • J. T. Stinis
  • A. Montfoort
  • W. C. Hülsmann

Abstract

The specific biochemical derangements that lead to the rapid loss of contractile function and enhancement of cardiac excitability after the interruption of myocardial bloodflow are not yet settled. However, it may involve either a cellular depletion of high energy compounds (1), an accumulation of noxious products such as H+ ions and lipid intermediates (2–6), and/or alteration in the functional properties of subcellular membranes (7–10). Abnormalities found in membrane preparations purified from the ischemic heart are most likely irreversible defects. These destructive changes may be caused by degradation of membrane phospholipids or proteins by activated phospholipases and proteases, respectively.

Keywords

Free Fatty Acid Sarcoplasmic Reticulum Membrane Function Sarcoplasmic Reticulum Membrane Cytosolic Side 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • J. M. J. Lamers
    • 1
  • J. T. Stinis
    • 1
  • A. Montfoort
    • 1
  • W. C. Hülsmann
    • 1
  1. 1.Departments of Biochemistry I and Pathological, Anatomy IErasmus UniversityRotterdamThe Netherlands

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