Advertisement

A Surface Charge Hypothesis for the Actions of Palmitylcarnitine on the Kinetics of Excitatory Ionic Currents in Heart

  • A. J. Pappano
  • D. Inoue

Abstract

The relationship between increased levels of free fatty acids (FFA) and the increased incidence of severe arrhythmias reported by Kurien and Oliver (1) in the pathogenesis of ischemic heart disease has prompted a critical examination of the mechanisms by which changes in lipid metabolism disturb the regulation of ion transport in cardiac membranes. This concept has been modified to include the possibility that long chain fatty acid derivatives (acyl carnitine; 2) and lysophosphatidylcholine, which accumulate in the ischemic heart, can alter ion transport in cardiac membranes (reviewed in 3, 4). These reviews have also addressed the molecular mechanisms by which these lipid metabolites alter membrane structure and thereby change the function of transport proteins in the sarcoplasmic reticulum and plasma membrane.

Keywords

Stimulus Frequency Purkinje Fiber Ventricular Muscle Cardiac Membrane Cardiac Fiber 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Kurien, V.A., & Oliver, M.F. (1966): Lancet 2: 122.PubMedCrossRefGoogle Scholar
  2. 2.
    Liedtke, A.J., Nellis, S., & Neely, J.R. (1978): Circ. Res. 43: 652.PubMedGoogle Scholar
  3. 3.
    Katz, A.M., & Messineo, F.C. (1981): Circ. Res. 48: 1.PubMedGoogle Scholar
  4. 4.
    Corr, P.B., & Sobel, B.E. (1982): In Ventricular Tachycardia: Mechanisms and Management (ed) M.E. Josephson, Futura Publishing Co., Mount Kisco, N.Y., p. 97.Google Scholar
  5. 5.
    Arnsdorf, M.F., & Sawicki, G.J. (1981): Circ. Res. 49: 16.PubMedGoogle Scholar
  6. 6.
    Corr, P.B., Cain, M.E., Witkowski, F.X., Price, D.A., & Sobel, B.E. (1979): Circ. Res. 44: 822.PubMedGoogle Scholar
  7. 7.
    Corr, P.B., Snyder, D.W., Cain, M.E., Crafford, W.A., Gross, R.W., & Sobel, B.E. (1981): Circ. Res. 49: 354.PubMedGoogle Scholar
  8. 8.
    Inoue, D., & Pappano, A.J. (1983): Circ. Res. 52: 625.PubMedGoogle Scholar
  9. 9.
    Hoak, J.C., Connor, W.E., & Warner, E.D. (1968): J. Clin. Invest. 47: 2701.PubMedCrossRefGoogle Scholar
  10. 10.
    Hoak, J.C., Connor, W.E., & Warner, E.D. (1967): J. Clin. Invest. 46: 1071.Google Scholar
  11. 11.
    Inoue, D., Hachisu, M., & Pappano, A.J. (1983): Circ. Res. 53: 158.PubMedGoogle Scholar
  12. 12.
    Iijima, T., & Pappano, A.J. (1979): Circ. Res. 44: 358.PubMedGoogle Scholar
  13. 13.
    Higgins, D., & Pappano, A.J. (1981): Circ. Res. 48: 245.PubMedGoogle Scholar
  14. 14.
    Walton, M., & Fozzard, H.A. (1979): Biophys. J. 25: 407.PubMedCrossRefGoogle Scholar
  15. 15.
    Marcus, N.C., & Fozzard, H.A. (1981): J. Mol. Cell. Cardiol. 13: 335.PubMedCrossRefGoogle Scholar
  16. 16.
    Carmeliet, E., & Vereecke, J. (1979): In Handbook of Physiology, Section 2: The Cardiovascular System, Vol. I . The Heart (ed) R.M. Berne, American Physiological Society, Bethesda, Maryland, p. 269.Google Scholar
  17. 17.
    Frankenhaeuser, B., & Hodgkin, A.L. (1957): J. Physiol. (London) 137: 218.Google Scholar
  18. 18.
    Jack, J.J.B., Noble, D., & Tsien, R.W. (1975): Electric Current Flow in Excitable Cells, Clarendon Press, Oxford.Google Scholar
  19. 19.
    Gettes, L.S., & Reuter, H. (1974): J. Physiol. (London) 240: 703.Google Scholar
  20. 20.
    Weld, F.M., & Bigger, J.T. (1975): Circ. Res. 37: 630.PubMedGoogle Scholar
  21. 21.
    Brown, A.M., Lee, K.S., & Powell, T. (1981): J. Physiol. (London) 318: 479.Google Scholar
  22. 22.
    Cohen, C.J., Bean, B.P., Colatsky, T.J., & Tsien, R.W. (1981): J. Gen. Physiol. 78: 383.PubMedCrossRefGoogle Scholar
  23. 23.
    Saikawa, T., & Carmeliet, E. (1982): Pflugers Arch. 394: 90.PubMedCrossRefGoogle Scholar
  24. 24.
    Hachisu, M., & Pappano, A.J. (1983): J. Pharmacol. Exp. Ther. 225: 112.PubMedGoogle Scholar
  25. 25.
    Reuter, H. (1982): In Normal and Abnormal Conduction in the Heart (eds) A.P. Paes de Carvalho, B.F. Hoffman, & M. Lieberman, Futura Press, Mount Kisco, NY, p. 277.Google Scholar
  26. 26.
    Hille, B., Woodhull, A.M., & Shapiro, B.I. (1975): Phil. Trans. R. Soc. Lond. B. 270: 301.CrossRefGoogle Scholar
  27. 27.
    Isenberg, G. (1975): Nature 253: 273.CrossRefGoogle Scholar
  28. 28.
    Bassingthwaighte, J.B., Fry, C.H., & McGuigan, J.A.S. (1976): J. Physiol. (London) 262: 15.Google Scholar
  29. 29.
    Kass, R.S., & Tsien, R.W. (1976): J. Gen. Physiol. 67: 599.PubMedCrossRefGoogle Scholar
  30. 30.
    Adams, R.J., Cohen, D.W., Gupte, S., Johnson, J.D., Wallick, E.T., Wang, T., & Schwartz, A. (1979): J. Biol. Chem. 254: 12404.PubMedGoogle Scholar
  31. 31.
    Messineo, F.C., Pinto, P.B., & Katz, A.M. (1982): In Advances in Myocardiology, Vol. 3 (eds) E. Chazov, V. Smirnov, & N.S. Dhalla, Plenum Publishing Corp., New York, p. 407.Google Scholar
  32. 32.
    Pitts, B.J.R., Tate, C.A., Van Winkle, W.B., Wood, J.M., & Entman, M.L. (1978): Life Sci. 23: 391.PubMedCrossRefGoogle Scholar
  33. 33.
    Gross, R.W., Corr, P.B., Lee, B.I., Saffitz, J.E., Crawford, W.A., & Sobel, B.E. (1982): Circ. Res. 51: 27.PubMedGoogle Scholar
  34. 34.
    Feuvray, D., Idell-Wenger, J.A., & Neely, J.R. (1979): Circ. Res. 44: 322.PubMedGoogle Scholar
  35. 35.
    Corr, P.B., Snyder, D.W., Lee, B.I., Gross, R.W., Keim, C.R., & Sobel, B.E. (1982): Am. J. Physiol. 243: H187.PubMedGoogle Scholar
  36. 36.
    Opie, L.H. (1979): Am. Heart J. 97: 375.PubMedCrossRefGoogle Scholar
  37. 37.
    Hondeghem, L.M., & Katzung, B.G. (1977): Biochim. Biophys. Acta 472: 373.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • A. J. Pappano
    • 1
  • D. Inoue
    • 1
  1. 1.Department of PharmacologyUniversity of Connecticut Health CenterFarmingtonUSA

Personalised recommendations