Lipids are essential for normal myocardial function; free fatty acids, for example, represent the major substrate for cardiac energy production, and a variety of complex lipids play essential structural and functional roles in the heart. Under certain circumstances, however, abnormalities in lipid metabolism can be harmful to the heart. A large body of recent experimental findings has shown that the abnormal accumulation of certain classes of lipid can impair myocardial function and, at high concentrations, may lead to cell death. Over the past decade, these detrimental effects of lipids have attracted the attention of basic scientists who study the response of the heart to disease, and physicians charged with the care of the cardiac patient. Major advances in both the medical and surgical therapy of cardiac diseases, notably the wide use of open-heart surgery and a growing number of interventions for the therapy of coronary occlusion and myocardial infarction, have brought this subject to the forefront of research in Cardiology.
KeywordsFree Fatty Acid Ischemic Heart Sarcoplasmic Reticulum Fatty Acyl Myocardial Function
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