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Clinical Relevance of Free Fatty Acid Excess

  • L. H. Opie
  • M. J. Tansey
  • J. de Leiris

Abstract

A large part of this book is devoted to abnormalities of myocardial lipid metabolism and to the possible disturbances thereof in ischemia. This article emphasizes the importance not only of changes in lipid but also of carbohydrate metabolism and the interaction of these two, with special reference to clinical situations. In acute myocardial infarction, there is a general metabolic disturbance (1), quite apart from the changes occurring in the myocardial muscle. There is a release of catecholamines with increased circulating and urinary values with an elevation of blood free fatty acids (= FFA = NEFA = non-esterified fatty acids), and the development of glucose intolerance. There is reasonable and increasing evidence that each of these abnormalities may play an important role in the evolution of myocardial ischemic injury. The fundamental change may be the increased circulating catecholamines which probably elevate the blood free fatty acids. The glucose tolerance probably results both from the elevation of circulating free fatty acids and also from the effect of catecholamines on the release of insulin from the pancreas.

Keywords

Free Fatty Acid Infarct Size Enzyme Release High Free Fatty Acid Coronary Ligation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • L. H. Opie
    • 1
  • M. J. Tansey
    • 1
  • J. de Leiris
    • 1
  1. 1.MRC-UCT Ischemic Heart Disease Research Unit Department of MedicineUniversity of Cape TownCape TownSouth Africa

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