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Phospholipase and Ischemic Damage: Possibilities of Interventions

  • M. Chiariello
  • G. Ambrosio
  • M. Cappelli-Bigazzi
  • G. Marone
  • M. Condorelli

Abstract

It has been recently suggested that derangement of phospholipid metabolism may represent one of the prominent biochemical changes leading to the production of irreversible injury during cellular ischemia (1–3). In the ischemic liver, a close correlation was found between the development of irreversible cell damage and the rate of degradation of microsomal membrane phospholipids. More recently, an accelerated phospholipid degradation was demonstrated also in the ischemic myocardium (4).

Keywords

Coronary Occlusion Ischemic Damage Coronary Artery Occlusion Phospholipase Activation Phospholipid Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • M. Chiariello
    • 1
  • G. Ambrosio
    • 1
  • M. Cappelli-Bigazzi
    • 1
  • G. Marone
    • 1
  • M. Condorelli
    • 1
  1. 1.Department of Internal Medicine, Second School of MedicineUniversity of NaplesNaplesItaly

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