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Fatty Acid and Carnitine-Linked Abnormalities During Ischemia and Cardiomyopathy

  • A. L. Shug
  • D. J. Paulson

Abstract

Myocardial ischemia, a condition whereby reduced perfusion provides an insufficient supply of oxygen to the heart, begins with potentially reversible metabolic and physiological changes which last about 20 minutes (1, 2). Many of these changes seem geared to protect the heart during periods of oxygen deficiency (3). Nevertheless, if perfusion is not restored within this period, irreversible changes in metabolism, structure and function occur, and ultimately the condition will lead to myocardial infarction and cellular death (1, 4, 5).

Keywords

Left Atrial Creatine Phosphate Free Carnitine Adenine Nucleotide Translocator Carnitine Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Hillis, L.D., & Braunwald, E. (1977): N. Engl. J. Med. 296: 971.PubMedCrossRefGoogle Scholar
  2. 2.
    Jennings, R.B., & Ganote, C.E. (1976): Circ. Res. 38 (Suppl. 1): 180.Google Scholar
  3. 3.
    Katz, A.M. (1973): Am. J. Cardiol. 32: 46.CrossRefGoogle Scholar
  4. 4.
    Neely, J.R., & Morgan, H.E. (1974): Ann. Rev. Physiol. 36: 413.Google Scholar
  5. 5.
    Jennings, R.B., Ganote, C.E., & Reimer, K.A. (1975): Am. J. Pathol. 31: 179.Google Scholar
  6. 6.
    Jacobus, W.E., & Lehninger, A.L. (1973): J. Biol. Chem. 246: 4303.Google Scholar
  7. 7.
    Pfaff, E., & Klingenberg, M. (1963): Eur. J. Biochem. 6: 66.CrossRefGoogle Scholar
  8. 8.
    Bessman, S.P., & Geiger, P.J. (1968): Science 211: 448.CrossRefGoogle Scholar
  9. 9.
    Stull, J.T., & Buss, J.E. (1977): J. Biol. Chem. 252: 851.PubMedGoogle Scholar
  10. 10.
    Shug, A.L., Koke, J.R., Folts, J.D., & Bittar, N. (1975): IN Recent Advances in Studies on Cardiac Structure and Metabolism, University Park Press, Baltimore, vol. 10, p. 365.Google Scholar
  11. 11.
    Huth, P.J., Thomsen, J.H., & Shug, A.L. (1978): Life Sci. 23: 715.PubMedCrossRefGoogle Scholar
  12. 12.
    Bremer, J. (1977): TIBS 2: 207.Google Scholar
  13. 13.
    Tubbs, P.K., Ramsay, R.R., & Edwards, M.R. (1980): IN Carnitine Biosynthesis,Metabolism, and Functions, (eds) R.A. Frenkel and J.D. McGarry, Academic Press, New York, p. 207.Google Scholar
  14. 14.
    Neely, J.R., Denton, R.M., England, P.J., & Randle, P.J. (1972): Biochem. J. 128: 147.PubMedGoogle Scholar
  15. 15.
    Goodwin, J.F. (1974): Circulation 50: 210.PubMedGoogle Scholar
  16. 16.
    Olsen, E.G. (1975): Postgrad. Med. I 51: 295.Google Scholar
  17. 17.
    Kako, K.J., Thornton, M.J., & Heggtveit, H.A. (1974): Circ. Res. 34: 570.PubMedGoogle Scholar
  18. 13.
    Wittels, B., & Bressler, R. (1964): J. Clin. Invest. 43: 630.PubMedCrossRefGoogle Scholar
  19. 19.
    Engel, A.G. (1980): IN Carnitine Biosynthesis. Metabolism, and Functions, (eds) R.A. Frenkel and J.D. McGarry, Academic Press, New York, p. 271.Google Scholar
  20. 20.
    Chapoy, P.R., Angelini, C., Brown, W.J., Stiff, J.E., & Shug, A.L. (1980): N. Engl. J. Med. 303: 1389.PubMedCrossRefGoogle Scholar
  21. 21.
    Tripp, M.E., Katcher, M.L., Peters, H.A., Gilbert, E.F., Arya, S., Hodach, R.J., & Shug, A.L. (1981): N. Engl. J. Med. 305: 385.PubMedCrossRefGoogle Scholar
  22. 22.
    Waber, L.J., Valle, D., Neill, C., DiMauro, S., & Shug, A.L. (1982): J. Pediatr. 101: 700.PubMedCrossRefGoogle Scholar
  23. 23.
    Shug, A.L., Thomsen, J.D., Folts, J.D., Bittar, N., Klein, M.I., Koke, J.R., & Huth, P.J. (1973): Arch. Biochera. Biophys. 187: 25.CrossRefGoogle Scholar
  24. 24.
    Christiansen, R., Borrebaek, B., & Bremer, J. (1976): FEBS Lett. 62: 313.PubMedCrossRefGoogle Scholar
  25. 25.
    Shug, A.L., Huth, P.J., Hayes, B., Thomsen, J.H., Hall, P.V., Bittar, N., & Demling, R.J. (1980): IN Carnitine Biosynthesis. Metabolism and Functions. (eds) R.A. Frenkel and J.D. McGarry, Academic Press, New York, p. 321.Google Scholar
  26. 26.
    Moore, K.H., Radloff, J.F., Hull, F.E., & Sweeley, C.C. (1980): Am. J. Physiol. 239: H257.PubMedGoogle Scholar
  27. 27.
    Folts, J.D., Shug, A.L., Koke, J.R., & Bittar, N. (1978): Am. J. Cardiol. 41: 1209.PubMedCrossRefGoogle Scholar
  28. 28.
    Neely, J.R., & Rovetto, J.M. (1975): IN Methods of Enzytaology, (eds) B.W. O’Malley & J.G. Hartman, Academic Press, New York, Vol. 39, p. 43.Google Scholar
  29. 29.
    Hayes, B.E. (1980): Ph.D. Thesis, university of Wisconsin, Madison, Wisconsin.Google Scholar
  30. 30.
    Böhmer, T., Rydning, A., & Solberg, U.E. (1974): Clin. Chic. Acta 57: 55.CrossRefGoogle Scholar
  31. 31.
    Veloso, D., & Veech, R.L. (1974): Anal. Biochem. 62: 449.PubMedCrossRefGoogle Scholar
  32. 32.
    Oram, J.F., Wengner, I.I., & Neely, J.R. (1975): J. Biochem. 250: 73.Google Scholar
  33. 33.
    Paulson, D.J., & Shug, A.L. (1982): Circulation 66: 434.Google Scholar
  34. 34.
    Shug, A.L., Shrago, E., Bittar, K., Folts, J.D., & Koke, J.R. (1975): Am. J. Physiol. 228: 689.PubMedGoogle Scholar
  35. 35.
    Shug, A.L. (1979): Texas Reports Biol. Med. 39: 409.Google Scholar
  36. 36.
    Shug, A.L. personal observations.Google Scholar
  37. 37.
    Regitz, V., Paulson, D.J., Hodach, R.J., Little, S.S., Schaper, W., & Shug, A.L. (1984): Basic Res. Cardiol. 195: In press.Google Scholar
  38. 38.
    Falcone, A.B., & Mao, R.L. (1965): Biochira. Biophys. Acta 105: 233.Google Scholar
  39. 39.
    Shug, A.L., Lerner, E., Elson, C., & Shrago, E. (1971): Biochem. Biophys. Res. Commun. 43: 557.PubMedCrossRefGoogle Scholar
  40. 40.
    Idell-Wenger, J.A., Grotyohann, L.U., & Neely, J.R. (1978): J. Biol. Chenu 253: 4310.Google Scholar
  41. 41.
    Iloppel, C.L., Taadler, B., Par land, W., Turkaly, J.S., & Albers, L.D. (1931): J. Biol. Chem. 257: 1540.Google Scholar
  42. 42.
    Tripp, M.E., & Shug, A.L. (1983): J. Am. Coll. Cardiol. 1: 724.Google Scholar
  43. 43.
    Feuvray, D., & Plouet, J. (1981): Circ. Res. 48: 740.PubMedGoogle Scholar
  44. 44.
    Challoner, D.R., & Prals, H.J. (1972): J. Clin. Invest. 51: 2071.PubMedCrossRefGoogle Scholar
  45. 45.
    Liedtke, A.J., Nellis, S.H., St Copenhaver, G. (1979): J. Clin. Invest. 64: 440.PubMedCrossRefGoogle Scholar
  46. 46.
    Suzuki, J., Kamikawa, T., & Yamazaki, N. (1980): IN Carnitine Biosynthesis. Metabolism, and Functions, (eds.) R.A. Frenkel & J.D. McGarry, Academic Press, Hew York, p. 341.Google Scholar
  47. 47.
    Thomsen, J.H., Shug, A.L., Yap, V.U., Patel, A.K., Xarras, T.J., & DeFelice, S.L. (1979): Am. J. Cardiol. 43: 300.PubMedCrossRefGoogle Scholar
  48. 48.
    Cherci, A., Fonzo, R., Lai, C., Mercuro, G., & Corsi, M. (1978): Boll. Soc. Ital. Cardiol. 23: 71.Google Scholar
  49. 49.
    Neely, J.R., Garber, D., McDonough, K., & Idell-Wenger, J. (1979): IN Ischemic Myocardium and Antianginal Drugs, (eds) M.M. Winbury & Y. Abiko, Raven Press, New York, p. 225.Google Scholar
  50. 50.
    Bressler, R. (1970): IN Lipid Metabolism, (ed) S.J. Wakil, Academic Press, New York, p. 49.Google Scholar
  51. 51.
    Molstad, P. (1980): Biochim. Biophys. Acta 597: 166.PubMedCrossRefGoogle Scholar
  52. 52.
    Pande, S.V., & Parvin, R. (1976): J. Biol. Chem. 251: 6683.PubMedGoogle Scholar
  53. 53.
    Bahl, J.J., Navin, T.R., & Bressler, R. (1980): IN Carnitine Biosynthesis. Metabolism, and Functions, (eds) R.A. Frenkel & J.D. McGarry, Academic Press, New York, p. 91.Google Scholar
  54. 54.
    Pande, S.V., & Parvin, R. (1980): J. Biol. Chem. 255: 2994.PubMedGoogle Scholar
  55. 55.
    Thomsen, J.H., personal communication.Google Scholar
  56. 56.
    Vary, T.C., & Neely, J.R. (1982): Am. J. Physiol. 242: H585.PubMedGoogle Scholar
  57. 57.
    Paulson, D.J., & Shug, A.L. (1981): Life Sci. 28: 2931.PubMedCrossRefGoogle Scholar
  58. 58.
    Spagnoli, L.G., Corsi, M., Villaschi, S., Palraieri, G., & Maccari, F. (1982): Lancet June 19: 1419.CrossRefGoogle Scholar
  59. 59.
    Katz, A.M., & Messineo, F.C. (1982): J. Mol. Cell. Cardiol. 14: 119.PubMedCrossRefGoogle Scholar
  60. 60.
    Crass, M.F. (1979): IN Metabolic and Morphologic Correlates in Cardiovascular Function, (eds) M.F. Crass & L.A. Sordahl, University of Texas Medical Branch, Galveston, p. 439.Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • A. L. Shug
    • 1
  • D. J. Paulson
    • 1
  1. 1.Department of NeurologyUniversity of Wisconsin and Veterans HospitalMadisonUSA

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