Factors that Influence Myocardial Levels of Long-Chain Acyl CoA and Acyl Carnitine

  • J. R. Neely
  • K. H. McDonough


High levels of fatty acids frequently have been found to be detrimental to ischemic myocardium (for review see 1). The mechanism of these effects is not understood but several possibilities exist. First, it seems very clear that fatty acids increase myocardial oxygen consumption when compared to carbohydrates (2, 3). The theoretical increase in oxygen consumption if the heart were using 100% lipid compared to 100% carbohydrate is about 13%. However, increases in oxygen consumption at constant workload caused by high levels of fatty acids range from 20 to 50% (2, 3). Obviously, this increase in oxygen consumption under conditions of limited oxygen supply, such as ischemia, may place the heart in a negative energy balance and precipitate a compensatory reduction in function.


Lipase Activity Coronary Flow Acetyl Ester Exogenous Fatty Acid Acyl Ester 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • J. R. Neely
    • 1
  • K. H. McDonough
    • 2
  1. 1.Department of PhysiologyThe Milton S. Hershey Medical CenterHersheyUSA
  2. 2.Department of PhysiologyLouisiana State University Medical CenterNew OrleansUSA

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