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Significance of the Kinetics of Immunotoxin Cytotoxicity

  • F. K. Jansen
  • H. E. Blythman
  • B. Bourrie
  • D. Carriere
  • P. Casellas
  • D. Dussossoy
  • O. Gros
  • J. C. Laurent
  • M. C. Liance
  • P. Poncelet
  • G. Richer
  • H. Vidal

Abstract

Since 1980, immuno-A-toxins (I-A-Ts) which are conjugates between an antibody and the A-chain of a polypeptide toxin, e.g., diphtheria toxin or ricin, have been described by several laboratories as cytotoxic agents with high specificity for their target cells.1–15 However, there was great variation from high to low potency depending on the antigen-immunotoxin (IT) system used. The advantage of the I-A-Ts is their low non-specific toxicity in-vivo (LD/50 in mice 20mg/kg),16 which will allow their utilization in human patients in the near future.

Keywords

Ammonium Chloride Human Bone Marrow Protein Synthesis Inhibition Diphtheria Toxin Autologous Bone Marrow Transplantation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • F. K. Jansen
    • 1
  • H. E. Blythman
    • 1
  • B. Bourrie
    • 1
  • D. Carriere
    • 1
  • P. Casellas
    • 1
  • D. Dussossoy
    • 1
  • O. Gros
    • 1
  • J. C. Laurent
    • 1
  • M. C. Liance
    • 1
  • P. Poncelet
    • 1
  • G. Richer
    • 1
  • H. Vidal
    • 1
  1. 1.Section ImmunologieCentre de Recherches Clin-MidyMontpellierFrance

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