Monoclonal Antibodies as Cell Targeted Carriers of Covalently and Non-Covalently Attached Toxins

  • Vic Raso
  • Marylu Basala


The strategy of using cell specific monoclonal antibodies to modify the indiscriminate binding characteristics of lethal toxins has stimulated considerable interest because of its therapeutic potential. Intact plant or bacterial toxins linked to antibodies may acquire some cell selectivity but because toxin binding sites are retained, non-specific toxicity can still occur. Since the binding region of such toxins is distinct from the enzymatically active toxic portion, these components can be cleaved and isolated (Olsnes and Pihl, 1973). Thus, purified toxic subunits can be coupled to antibodies to produce highly selective cytotoxic agents which are devoid of residual toxin binding.


Daudi Cell Chain Conjugate Bovine Gamma Globulin Human Gamma Globulin Rabbit Reticulocyte Lysate System 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Vic Raso
    • 1
  • Marylu Basala
    • 1
  1. 1.Department of PathologyHarvard Medical School and the Dana-Farber Cancer InstituteUSA

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