How do Protein Toxins Kill Cells?
Diphtheria toxin and ricin, the toxins most frequently used in attempts to construct target-specific cytostatic agents, belong to a group of closely related toxic proteins produced by bacteria and plants. The main reason why these toxins are used for this purpose is their extreme toxicity. This is due to the fact that the active moieties of the toxins possess enzymatic activity. A single molecule may inactivate components required for protein synthesis more rapidly than the cell can produce new ones and hence kill the cell in the course of a few hours.
KeywordsVero Cell Diphtheria Toxin Cyanogen Bromide Endocytic Vesicle Toxin Binding
Unable to display preview. Download preview PDF.
- Eiklid, K. and Olsnes, S. 1980, Interaction of Shigella Shigae cytotoxin with receptors on sensitive and insensitive cells, J. Receptor Res., 1: 199.Google Scholar
- Olsnes, S. and Pihl, A. 1982, in “The molecular action of toxins and viruses”, P. Cohen and S. van Heyningen, eds. Elsevier/ North Holland, Amsterdam.Google Scholar
- 01.Snes, S., Reisbig, R. and Eiklid, K. 1981, Subunit structure of Shigella cytotoxin, J. Biol. Chem., 256: 8732.Google Scholar
- Olsnes, S., Sandvig, K., Refsnes, K. and Pihl, A. 1976, Rates of different steps involved in the inhibition of protein synthesis by the toxic lectins abrin and ricin, J. Biol. Chem., 257: 3985.Google Scholar