Drug Targeting in Cancer Therapy

  • George Poste


Progress in cancer chemotherapy over the last twenty years has produced important gains in the treatment of testicular germ cell tumors, choriocarcinoma, Burkitt’s lymphoma, Hodgkins disease, and several childhood cancers.1 Progress in treating the three most common solid malignancies of man arising in breast, lung and colon is less impressive, however, and the majority of patients with these tumors die of metastatic disease, despite assault by ever larger combinations of drugs. Two factors are responsible for limiting the effectiveness of current therapeutic approaches. First, the presence within the same tumor of subpopulations of cells that differ widely in their responses to cytotoxic drugs and other agents used in cancer treatment means that therapy will be successful only if this diversity can be circumvented.2,3 Second, the lack of selectivity of most anticancer agents for tumor cells causes significant toxicity to normal tissues with resulting problems in clinical management, patient compliance and reduced quality of life.


Drug Carrier Target Drug Delivery Particulate Carrier Extravascular Compartment Fenestrated Capillary 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • George Poste
    • 1
    • 2
  1. 1.Smith Kline and French LaboratoriesPhiladelphiaUSA
  2. 2.Department of Pathology and Laboratory MedicineUniversity of Pennsylvania Medical SchoolPhiladelphiaUSA

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