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Targeting and Lysosomal Handling of Polymethacrylamide-Oligopeptide Conjugates

  • J. B. Lloyd
  • R. Duncan
  • J. Kopeček
  • P. Rejmanová

Abstract

In the previous volume in this series, Trouet et al., (1982) explained the concept of the lysosomotropic drug-carrier conjugate and prescribed the necessary conditions for this approach to chemotherapy to succeed. We are engaged in the preparation and testing of such a conjugate, and here present a progress report on our work.

Keywords

Synthetic Polymer Lysosomal Enzyme Amide Linkage Terminal Amino Acid Distal Amino Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Cartlidge, S.A., Duncan, R., Lloyd, J.B., Rejmanová, P., and Kopeček, J., 1982, Pinocytic capture and intracellular degradation of poly N-(2-hydroxypropyl)-methacrylamide chains connected by oligopeptide sequences, Proc. Internat. Conf. Biomedical Polymers, Durham, 289.Google Scholar
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • J. B. Lloyd
    • 1
  • R. Duncan
    • 1
  • J. Kopeček
    • 2
  • P. Rejmanová
    • 2
  1. 1.Biochemistry Research Laboratory, Department of Biological SciencesUniversity of KeeleStaffordshireEngland
  2. 2.Institute of Macromolecular ChemistryCzechoslovak Academy of SciencesPragueCzechoslovakia

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