The Use of Liposomes in Diagnostic Imaging
The delivery of drugs to organs is determined by blood flow, lipid-water partition coefficient of the drug, ionization, drug stability and chemical structure. Using drug carriers the pharmacokinetics can be changed to make possible the selective drug delivery to normal and pathological tissues. Besides protecting the drug, the carrier facilitates the movement of the drug across anatomic and biochemical barriers to selected cells, tissues or organs (Gregoriadis, 1978). The three elements that influence drug distribution via carriers and are susceptible to manipulation are the drug carrier itself, the route (including the administration route and the path between the site of administration and the final destination) and the target tissue. Drug carriers, route and target have specific chemical, physical and anatomical features that deserve special consideration.
KeywordsContrast Agent Drug Carrier Lipid Vesicle Administration Route Organ Distribution
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- Caride, V.J., 1981, Liposomes for diagnostic imaging, in: “Radiopharmaceuticals: structure activity relationships”, R.P. Spencer, ed., Grune & Stratton, New York.Google Scholar