Thrombogenic Potential of Phosphatidylserine-Containing Liposomes

  • G. B. Humphrey
  • L. V. Allen
  • R. Blackstock
  • P. C. Comp
  • L. E. De Bault
  • C. T. Esmon
  • A. Harriman
  • F. A. Holloway
  • H. F. Krous
  • M. Mojarad
  • H. L. Stone
  • R. Wierimaa

Abstract

By the spring of 1981, Fidler and Poste and their co-workers had demonstrated that monocytes could be activated to become tumoricidal after incubation with liposomes containing monocyte/macrophage activating agents (Fidler, 1975; Fidler et al., 1976). These same phosphatidylcholine (PC), phosphatidylserine (PS) liposomes containing muramyl dipeptide (MDP) or one of its derivatives could eradicate spontaneous metastases in mice (Fidler et al., 1981). Furthermore, no toxicity is observed when liposomes are administered intravenously to dogs and mice (Hart et al., 1981).

Keywords

Permeability Formalin Toxicity Depression Citrate 

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • G. B. Humphrey
    • 1
    • 2
  • L. V. Allen
    • 1
    • 2
  • R. Blackstock
    • 1
    • 2
  • P. C. Comp
    • 1
    • 2
  • L. E. De Bault
    • 1
    • 2
  • C. T. Esmon
    • 1
    • 2
  • A. Harriman
    • 1
    • 2
  • F. A. Holloway
    • 1
    • 2
  • H. F. Krous
    • 1
    • 2
  • M. Mojarad
    • 1
    • 2
  • H. L. Stone
    • 1
    • 2
  • R. Wierimaa
    • 1
    • 2
  1. 1.University of Oklahoma Health Sciences CenterUSA
  2. 2.Oklahoma State UniversityUSA

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