Thrombogenic Potential of Phosphatidylserine-Containing Liposomes
By the spring of 1981, Fidler and Poste and their co-workers had demonstrated that monocytes could be activated to become tumoricidal after incubation with liposomes containing monocyte/macrophage activating agents (Fidler, 1975; Fidler et al., 1976). These same phosphatidylcholine (PC), phosphatidylserine (PS) liposomes containing muramyl dipeptide (MDP) or one of its derivatives could eradicate spontaneous metastases in mice (Fidler et al., 1981). Furthermore, no toxicity is observed when liposomes are administered intravenously to dogs and mice (Hart et al., 1981).
KeywordsMultilamellar Vesicle Spontaneous Metastasis Muramyl Dipeptide Cancer Procoagulant Pulmonary Microcirculation
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