Endocytosis of Liposomes and Intracellular Fate of Encapsulated Molecules: Strategies for Enhanced Cytoplasmic Delivery
Liposomes have evoked considerable interest as carriers of macromolecules, based on their ability to encapsulate a wide variety of biologically active materials and deliver them, functionally intact, to particular in-vivo or in-vitro compartments. Liposomes are adaptable to the requirements of a wide range of experimental conditions, since it is possible to alter such parameters as liposome size, surface charge, bilayer fluidity, and stability. Recently, several groups have shown that it is possible to couple covalently to the liposome surface a variety of ligands, such as immunoglobulins, to promote specificity of lipo-some-cell interaction and to increase the number of liposomes bound to or internalized by cells (Heath et al., 1980; Leserman et al., 1980; Heath et al., 1983).
KeywordsEndocytic Pathway Intracellular Delivery Phospholipid Vesicle Coated Vesicle Intracellular Fate
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