Development of Monoclonal Antibodies with Specificity for Human Epithelial Cells

  • Joyce Taylor-Papadimitriou
  • Andrew B. Griffiths


The technique developed by Kohler and Milstein (1975) for the directed production of monoclonal antibodies has had an enormous impact not only on the field of immunology but in every area of cellular and molecular biology, because such antibodies provide highly specific markers for molecules and cells. It is likely that monoclonal antibodies will also be of great importance in clinical medicine, in a number of areas, among which is the receptor-mediated targeting of drugs, toxins and isotopes. The potential of monoclonal antibodies as vehicles for drug targeting is obvious, and many laboratories are involved in attempts to produce antibodies which react specifically with components of tumour cell membranes not found in normal cells. The major solid tumours in man are carcinomas which develop from epithelial cells, and therefore the membrane of the malignant epithelial cell is of prime interest. It is probably fair to say that most of the antibodies reacting with malignant epithelial cells which have been produced so far, are tumour-associated rather than tumour-specific and show a positive reaction with some other normal cells, usually epithelial in origin.


Antigenic Determinant Human Mammary Epithelial Cell Large Molecular Weight Myeloma Cell Line Membrane Extract 
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© Plenum Press, New York 1984

Authors and Affiliations

  • Joyce Taylor-Papadimitriou
    • 1
  • Andrew B. Griffiths
    • 1
  1. 1.Imperial Cancer Research FundLondon WC2A 3PXUK

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