Selective Cytotoxicity of Ricin a Chain-Anti Carcinoembryonic Antibody Conjugates to Human Adenocarcinoma Cells
Studies of immunotoxins as selective anti-tumor agents have been performed primarily with hematologic tumor antigens, such as mouse T cell differentiation antigens (1, 2) and immunoglobulin on the surface of murine and human B cell leukemia cells (3–6). We have recently explored this approach utilizing antibodies directed against the carcinoembryonic antigen, CEA (7–9), a well described tumor-associated antigen of adult human solid malignancies.
KeywordsCarcinoembryonic Antigen LoVo Cell Leucine Incorporation Selective Cytotoxicity WiDr Cell
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