Drug Targeting in Human Cancer Chemotherapy
Drug targeting aims to restrict the access of pharmacological agents to selected cells. Theoretically, such a method should on one hand, decrease unsuitable side effects resulting from an interaction of the drugs with non target cells and, on the other hand, enhance the pharmacological activity by increasing the proportion of the administered drug found within the target cells. Our conceptual approach to this problem consists in linking drugs through a covalent bond to macromolecular carriers which are recognized by receptors or antigens present at the cell surface of the target cells and thereafter endocytosed to allow the release of the drug after hydrolysis of the covalent linkage by lysosomal enzymes.
KeywordsHuman Serum Albumin Human Hepatoma Renal Capsule Label Material Terminal Galactose
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