Clinical Features of Human T-Cell Leukemia/Lymphoma Virus (HTLV) Associated T-Cell Neoplasms

  • Hiroaki Mitsuya
  • Samuel Broder


Approximately seven years ago clinical investigators in Kyoto reported a rapidly fatal T-cell lymphoproliferative syndrome, which seemed to affect adult populations born in the Southwestern part of the Japanese archipelago, even though the population may have migrated to another area of Japan. They referred to this disease as adult T-cell leukemia, and to date over 300 patients have been described by several groups in Japan. The syndrome is characterized by the presence of pleomorphic neoplastic cells with the membrane markers of mature T-lymphocytes. Several other findings are common at presentation including lymphadenopathy, hepatomegaly, splenomegaly, cutaneous infiltration with neoplastic T cells, hypercalcemia (with or without lytic bone lesions), and interstitial pulmonary infiltrates. Characteristically, there was an absence of mediastinal tumor involvement.


Mycosis Fungoides Lytic Bone Lesion Acquire Immunodeficiency Disease Syndrome Cell Lymphoblastic Lymphoma Interstitial Pulmonary Infiltrate 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Hiroaki Mitsuya
    • 1
  • Samuel Broder
    • 1
  1. 1.Clinical Oncology ProgramMational Cancer InstituteBethesdaUSA

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