Presence of Oncogenes in Spontaneous Rat Tumors
The origin of cancer seems to be the consequence of some variation that results in uncontrolled cellular proliferation. Exciting discoveries have led to the concept that a cellular genetic element, an oncogene, is responsible for initiation or maintenance (or both) of the transforming state. Cellular DNA contains a highly conserved battery of potential transforming genes, called c-onc, that could be activated in a variety of ways (Bishop, 1982). Genomic DNA-transfection studies have shown that 30% of the DNA from many human tumors possess transforming activity (Krontiris, 1983). Several of these oncogenes are homologous to the transforming genes of two acute transforming retroviruses, the Harvey and Kirsten strains of murine sarcoma viruses (HaMSV and KiMSV, respectively; Cooper, 1982). The oncogenes of HaMSV and KiMSV were derived from rat normal cellular sequences during in vivo passage of murine leukemia viruses.
KeywordsSingle Cell Clone Murine Sarcoma Virus Induce Tumor Formation Human Oncogene Tumor Preparation
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