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Thyroid Neoplastic Transformation In Vitro and In Vivo

  • A. Fusco
  • P. P. Di Fiore
  • M. T. Berlingieri
  • G. Colletta
  • A. M. Cirafici
  • G. Portella
  • M. Santoro

Abstract

Oncogenic RNA viruses (retroviruses) can be classified, according to their biological and molecular features, into two broad groups: acute transforming retroviruses and chronically transforming retroviruses (1,2). Viruses from the latter group are able to induce tumors (above all lymphoid leukemias) with a long latency period and with low efficiency; they are not capable of transforming cells in culture and do not possess the specific genetic information coding for a transforming protein. The acute transforming retroviruses, on the other hand, induce tumors (above all sarcomas and non lymphoid leukemias) with a high efficiency and a short latency period; they are able to transform cells in culture and possess genomic sequences encoding for the transforming proteins (oncogenes) (1).

Keywords

Lymphoid Leukemia Short Latency Period Suitable Model System Murine Sarcoma Virus Abelson Murine Leukemia Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • A. Fusco
    • 1
  • P. P. Di Fiore
    • 1
  • M. T. Berlingieri
    • 1
  • G. Colletta
    • 1
  • A. M. Cirafici
    • 1
  • G. Portella
    • 1
  • M. Santoro
    • 1
  1. 1.Centro di Endocrinologia ed Oncologia Sperimentale del C.N.R., c/o Dipartimento di Biologia e Patologia Cellulare e MolecolareII Facoltà di Medicina e Chirurgia dell’ Università di NapoliNapoliItaly

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