Thyroid Neoplastic Transformation In Vitro and In Vivo
Oncogenic RNA viruses (retroviruses) can be classified, according to their biological and molecular features, into two broad groups: acute transforming retroviruses and chronically transforming retroviruses (1,2). Viruses from the latter group are able to induce tumors (above all lymphoid leukemias) with a long latency period and with low efficiency; they are not capable of transforming cells in culture and do not possess the specific genetic information coding for a transforming protein. The acute transforming retroviruses, on the other hand, induce tumors (above all sarcomas and non lymphoid leukemias) with a high efficiency and a short latency period; they are able to transform cells in culture and possess genomic sequences encoding for the transforming proteins (oncogenes) (1).
KeywordsLymphoid Leukemia Short Latency Period Suitable Model System Murine Sarcoma Virus Abelson Murine Leukemia Virus
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