Skip to main content

Modulation of Thyroid Epithelial Differentiation by Two Viral Oncogenes

  • Chapter
Genetic and Phenotypic Markers of Tumors

Abstract

The loss of the expression of a differentiated phenotype is one of the most interesting features of many tumors, either spontaneously occurring in humans, or experimentally induced into laboratory animals.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. M. Pacifici, D. Boettiger, K. Roby and H. Holtzer, Transformation of chondroblasts by Rous sarcoma virus and synthesis of the sulphated proteoglycan matrix, Cell 11:891 (1977).

    Article  PubMed  CAS  Google Scholar 

  2. E. Gionti, O. Capasso and R. Cancedda, The culture of chick embryo chondrocytes and the control of their differentiated functions, J. Biol. Chem. 258:7190 (1983).

    PubMed  CAS  Google Scholar 

  3. S.L. Adams, M.E. Sodel, B.H. Howard, K. Olden, K.M. Yamada, B. de-Crombrugghe and I. Pastan, Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts, Proc. Natl. Acad. Sci. USA 74:3399 (1977).

    Article  PubMed  CAS  Google Scholar 

  4. M.I. Parker, K. Judge and W. Gevers, Loss of type I procollagen gene expression in SV40-transformed human fibroblasts is accompanied by hypermethylation of these genes, Nucl. Acids Res. 10:5879 (1982).

    Article  PubMed  CAS  Google Scholar 

  5. T. Graf, N. Ade and H. Beug, Temperature sensitive mutant of avian erythroblastosis virus suggests a block of differentiation as mechanism of leukemogenesis, Nature 275:496 (1978).

    Article  PubMed  CAS  Google Scholar 

  6. J. Pierce and S.A. Aaronson, Balb and Harvey murine sarcoma virus transformation of a novel lymphoid progenitor cell, J. Exp. Med. 156:876 (1982).

    Article  Google Scholar 

  7. J. Pierce and S.A. Aaronson, In vitro transformation of murine pre-B lymphoid cells by Snyder-Theilen feline sarcoma virus, J. Virol. 46:993 (1983).

    PubMed  CAS  Google Scholar 

  8. B.E. Weissman and S.A. Aaronson, Balb and Kirsten murine sarcoma viruses alter growth and differentiation of EGF dependent Balb/c mouse epidermal cheratinocyte lines, Cell 32:599 (1983).

    Article  PubMed  CAS  Google Scholar 

  9. N. Auersperg, J.B. Hudson, E.G. Goddard and V. Klement, Transformation of cultured rat adrenocortical cells by Kirsten murine sarcoma virus (Ki MSV), Int. J. Cancer 19:81 (1977).

    Article  PubMed  CAS  Google Scholar 

  10. F.S. Ambesi-Impiombato, L.A.M. Parks and H.G. Coon, Culture of hormone-dependent epithelial cells from rat thyroids,Proc. Natl. Acad. Sci. USA 77:3455 (1980).

    Article  PubMed  CAS  Google Scholar 

  11. A. Fusco, A. Pinto, F.S. Ambesi-Impiombato, G. Vecchio and N. Tsuchida, Transformation of rat thyroid epithelial cells by Kirsten murine sarcoma virus, Int. J. Cancer 28:655 (1981).

    Article  PubMed  CAS  Google Scholar 

  12. A. Fusco, A. Pinto, D. Tramontano, G. Tajana, G. Vecchio and N. Tsuchida, Block in the expression of differentiation markers of rat thyroid epithelial cells by transformation with Kirsten murine sarcoma virus, Cancer Res. 42:618 (1982).

    PubMed  CAS  Google Scholar 

  13. G. Colletta, A. Pinto, P.P. Di Fiore, A. Fusco, M. Ferrentino, V.E. Avvedimento, N. Tsuchida and G. Vecchio, Dissociation between transformed and differentiated phenotype in rat thyroid epithelial cells after transformation with a temperature-sensitive mutant of the Kirsten murine sarcoma virus, Mol. Cell. Biol. 3:2099 (1983).

    PubMed  CAS  Google Scholar 

  14. A. Fusco, P.P. Di Fiore, M.T. Berlingieri, G. Colletta, A.M. Cirafici, G. Portella and M. Santoro, Thyroid neoplastic transformation in vivo and in vitro, this volume.

    Google Scholar 

  15. T.Y. Shih, M.O. Weeks, H.A. Young and E.M. Scolnick, Identification of a sarcoma virus-coded phosphoprotein in nonproducer cells transformed by Kirsten or Harvey murine sarcoma viruses, Virology 96:164 (1979).

    Article  Google Scholar 

  16. T.Y. Shih, M.O. Weeks, H.A. Young and E.M. Scolnick, P21 of Kirsten murine sarcoma virus is thermolabile in a viral mutant temperature sensitive for the maintenance of transformation, J. Virol. 31:546 (1979).

    PubMed  CAS  Google Scholar 

  17. G. Vecchio, L. Nitsch, G. Tajana, A. Pinto and A. Fusco, Experimental thyroid carcinogenesis by RNA tumor viruses, in “Advances in thyroid neoplasia 1981”, M. Andreoli et al. eds., Field Educational Italia, Roma, 1981.

    Google Scholar 

  18. R. Di Lauro, S. Obici, A.M. Acquaviva and C. G. Alvino, Construction of recombinant plasmids containing rat thyroglobulin mRNA sequences, Gene 19:117 (1982).

    Article  PubMed  Google Scholar 

  19. W. Ostertag, I.B. Pragnell, A. Fusco, D. Hughes, M. Freshney, B. Klein, C. Jasmin, J. Bilello, G. Warnecke and K. Vehemeyer, Studies on the biology and genetics of murine erythroleukemia viruses, in “Expression of differentiated functions in cancer cells”, R. F. Revoltella et al. eds., Raven Press, New York (1982).

    Google Scholar 

  20. I.B. Pragnell, A. Fusco, C. Arbuthnott, F. Smadja-Joffe, B. Klein, C. Jasmine and W. Ostertag, Analysis of Myeloproliferative sarcoma virus genome: limited changes in the prototype lead to altered target specifity, J. Virol. 38:952 (1981).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Plenum Press, New York

About this chapter

Cite this chapter

Di Fiore, P.P. et al. (1984). Modulation of Thyroid Epithelial Differentiation by Two Viral Oncogenes. In: Aaronson, S.A., Frati, L., Verna, R. (eds) Genetic and Phenotypic Markers of Tumors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4856-6_26

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4856-6_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4858-0

  • Online ISBN: 978-1-4684-4856-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics