Modulation of Ia Antigens by Interferons in Human Lymphoid Cells

  • M. R. Capobianchi
  • F. Ameglio
  • R. Tosi
  • A. Dolei


As long as ten years ago it was shown that treatment with interferon (IFN) enhances the expression of Class I histocompatibility antigens (HLA — A, B,C) in mouse system1; the same was found to be true in human cells2. In later times, IFN was also shown to increase the expression and release of Class II (Ia) antigens3. Of the three types of IFN that are known so far, α, leukocytic, β, fibroblastic, and γ, immune IFN, the latter is the most effective in both instances4, in keeping with data from the literature, indicating that IFN γ is the most effective of the three as mediator of antitumor and anticellular activities5–7.


Coeliac Disease Human Lymphoid Cell Murine Leukemia L1210 Cell Namalva Cell Homozygous Cell Line 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • M. R. Capobianchi
    • 1
  • F. Ameglio
    • 2
  • R. Tosi
    • 2
  • A. Dolei
    • 1
    • 3
  1. 1.Istituto di VirologiaRomaItaly
  2. 2.Laboratorio di BiologiaCellulare del CNRRomaItaly
  3. 3.Patologia Generale per ScienzeCamerinoItaly

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