Membrane Changes Induced by Interferons in Human Neoplastic Cells

  • A. Dolei
  • F. Ameglio
  • M. R. Capobianchi
  • R. Tosi


A variety of important functions in the host have been attributed to the interferons (IFN). Among these, antiviral, cell-modulating and immunoregulatory activities are the most documented1. At least three antigenically distinct types of IFN have been identified so far: alpha, produced by B, natural killer cells and monocytes; beta, produced by fibroblast, epithelial cells and macrophages; and gamma, produced by sensitized or mitogen activated T lymphocytes. The antiviral effects as well as the effects on other cell functions may be activated by the three IFNs through different mechanisms of action2. Moreover, IFN gamma is a more potent mediator of antitumor and anticellular activities than IFN alpha and IFN beta3-5, especially with respect to functions related to the immune system5. It is conceivable that at least some of these activities may be connected to modulation of major histocompatibility complex-(MHC) -controlled components.


Major Histocompatibility Complex Major Histocompatibility Complex Expression Tigen Expression Namalva Cell Major Histocompatibility Complex Product 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • A. Dolei
    • 1
    • 3
  • F. Ameglio
    • 2
  • M. R. Capobianchi
    • 1
  • R. Tosi
    • 2
  1. 1.Istituto di VirologiaRomaItaly
  2. 2.Laboratorio di BiologiaCellulare del CNRRomaItaly
  3. 3.Patologia Generale per ScienzeCamerinoItaly

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