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Membrane Changes Induced by Interferons in Human Neoplastic Cells

  • A. Dolei
  • F. Ameglio
  • M. R. Capobianchi
  • R. Tosi

Abstract

A variety of important functions in the host have been attributed to the interferons (IFN). Among these, antiviral, cell-modulating and immunoregulatory activities are the most documented1. At least three antigenically distinct types of IFN have been identified so far: alpha, produced by B, natural killer cells and monocytes; beta, produced by fibroblast, epithelial cells and macrophages; and gamma, produced by sensitized or mitogen activated T lymphocytes. The antiviral effects as well as the effects on other cell functions may be activated by the three IFNs through different mechanisms of action2. Moreover, IFN gamma is a more potent mediator of antitumor and anticellular activities than IFN alpha and IFN beta3-5, especially with respect to functions related to the immune system5. It is conceivable that at least some of these activities may be connected to modulation of major histocompatibility complex-(MHC) -controlled components.

Keywords

Major Histocompatibility Complex Major Histocompatibility Complex Expression Tigen Expression Namalva Cell Major Histocompatibility Complex Product 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • A. Dolei
    • 1
    • 3
  • F. Ameglio
    • 2
  • M. R. Capobianchi
    • 1
  • R. Tosi
    • 2
  1. 1.Istituto di VirologiaRomaItaly
  2. 2.Laboratorio di BiologiaCellulare del CNRRomaItaly
  3. 3.Patologia Generale per ScienzeCamerinoItaly

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