Hyporesponsiveness of Natural Killer Activity Induced in Vivo By Multiple Treatment with Maleic Acid Anhydride Divinyl Ether (MVE-2)

  • Mario Piccoli
  • Angela Santoni
  • Francesca Velotti
  • M. Cristina Galli
  • Luigi Frati
  • Michael A. Chirigos

Abstract

The immunomodulators include a variety of biological and chemical compounds whose mechanisms of action involve the individual’s own biological responses. A modifier of the immune response should possess the following requirements:
  • lack of carcinogenicity or tumor enhancing influence;

  • no antigenicity;

  • defined effects on the components of the immune system;

  • known pharmacology;

  • low experimental and clinical toxicity.

Keywords

Cellulose Toxicity Depression Lymphoma Aspirin 

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Mario Piccoli
    • 2
  • Angela Santoni
    • 2
  • Francesca Velotti
    • 2
  • M. Cristina Galli
    • 2
  • Luigi Frati
    • 2
  • Michael A. Chirigos
    • 1
  1. 1.Immunopharmacology SectionBTB, BRMP, NCI, FCRFFrederickUSA
  2. 2.Istituto di Patologia GeneraleUniversità di RomaRomaItaly

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