Antitumor Adjuvants from Candida Albicans : Effects on Human Allogenic T-Cell Responses “In Vitro”
Candida albicans (CA) and other yeasts have recently been shown to act as strong, non-specific immunoadjuvants in combined chemoimmunotherapy in a mouse lymphoma model (1,2). Several cell wall fractions of distinct antigenicity and chemical composition have been used in “in vivo” experiments and showed a differential capacity of stimulating both anticancer effects and immunoresponsiveness (2). Other pieces of experimental evidence strongly suggest that the overall immunostimulating activity of yeast adjuvants depend on the potentiation of classical T-cell responses against products of minor histocompatibility loci or tumor-associated transplantation antigens of experimental, virus-induced tumors (2,3).
KeywordsCandida Albicans Cell Wall Fraction Mixed Lymphocyte Culture Histocompatibility Locus Mixed Lymphocyte Culture Reactivity
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