Modulating Effects of Thymic Factors on Natural Cell-Mediated Reactivities of Natural and Cyclophosphamide-Treated Mice
Our laboratory has been concerned for some time with the problem of the effects of in vivo administration of thymic extracts to mice on the expression of natural cell-mediated cytotoxicity against both fungal (1) and neoplastic cells (2) in intact as well as immunodepressed hosts. This seems particularly important because of the recent interest in the possiblc therapeutic use of thymus extracts (3, 4) and in consideration of the possible role of natural immunity in resistance mechanisms against neoplasia and microbial infections (5, 6). The issue is even more relevant when dealing with compromised hosts that are known to experience an increased susceptibility to infections and development of malignancies. In the present paper we report on the effects of thymus extract administrations in intact or cyclophosphamide treated mice on in vitro cell-mediated cytotoxicity against radiolabelled YAC-1 cells (7) and C. albicans particles (8).
KeywordsCandida Albicans Thymus Extract Charles River Breeding Laboratory Thymic Factor Candidacidal Activity
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