Abstract
In the last few years much interest has evolved in the study of natural reactivity (1). Studies from many laboratories have demonstrated that cells from different lymphoid tissues, including spleen and peripheral blood, show a spontaneous reactivity against neoplastic cells (2). This spontaneous reactivity, mediated by NK lymphocytes, has been shown to play a major role in the rapid elimination in vivo of neoplastic as well as of normal non-neoplastic targets including syngeneic bone marrow, thymocytes and fibroblasts (3–4). This reactivity directed against normal cells suggest an autocytotoxic function of NK effectors which could be involved in the homeostatic control of growth and differentiation of normal tissues (5–6). Also in vitro experiments showed some spontaneous reactivity against 51Cr-labelled non-neoplastic cells, but in this case it was not possible to obtain high cytotoxic levels of reactivity, comparable to those found against neoplastic targets (7–8). This fact is probably due to the low frequency of NK cells able to recognize “self” structures as targets. More recently it has been shown that it is possible to cultivate in vitro splenocytes of normal mice in the presence of T-cell-growth-factor (TCGF) and that these cultures generate lymphocytes with NK cell-like activity (9–10).
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References
Natural Resistance System Against Foreign Cell, Tumors and Microbes, eds. Cudkowicz G., Landy M., and Shearer G.M., Academic Press, New York, 1982.
NK Cells and Other Natural Effector Cells, ed. R.B. Herbermann, Academic Press, New York, 1982.
C. Riccardi, A. Santoni, T. Barlozzari and R.B. Herberman: Role of NK cells in rapid in vivo clearance of radio-labeled tumor cells. In “Natural Cell-Mediated Immunity Against Tumors” ed. R.B. Herberman, Academic Press, New York, p. 1121, 1980.
C. Riccardi, A. Santoni, T. Barlozzari, C. Cesarini and R.B. Herberman: In vivo role of NK cells against neo-plastic or non-neoplastic cells. In “Human Cancer Immunology”, North-Holland Press, vol.4 p. 57, 1982.
C. Riccardi, A. Santoni, T. Barlozzari and R.B. Herberman: In vivo Reactivity of mouse Natural Killer (NK) cells against Normal Bone Marrow Cells. Cell.Immunol., 60, 136, 1981.
G. Cudkowicz and P.S. Hochman: Do Natural Killer Cells Engage in Regulater Reactions Against Self to Ensure Homeostasis. Immunol. Rev., 44, 13, 1979.
M.E. Nunn, R.B. Herberman and H.T. Holden: Natural cell-mediated cytotoxicity in mice against nonlymphoid tumor cells and some normal cells. Int. J. Cancer, 20, 381, 1977.
M. Hansson, R. Kiessling, B. Andersson, K. Kärre and J. Roder: Natural Killer (NK) cell sensitive T-cell sub-population in the thymus: inverse correlation to NK activity of the host. Nature, 278, 174, 1979.
C. Riccardi, B.M. Vose and R.B.Herberman: Regulation by Interferon and T cells of IL-2-dependent growth of NK progenitor cells: a limiting dilution analysis. In “NK Celles and Other Natural Effector Cells” ed. R.B. Herberman, Academic Press, New York, pag. 909, 1982.
C. Riccardi, B.M. Vose and R.B. Herberman: Modulation of IL-2-dependent growth of mouse NK celles by interferon and T lymphocites. J. Immunol., 130, 228, 1983.
C. Riccardi, G. Migliorati and R.B. Herberman: Partially Restorative Role of T Cells for Low IL-2-Dependent Growth of NK Cell Progenitors from Nude Mice. Submitted for publication.
K. Nakano, I. Nakamura and G. Cudkowicz: Generation of F1 hybrid cytotoxic T lymphocytes specific for self H-2. Nature, 289, 559, 1981.
G.M. Shearer and G. Cudkowicz: Induction of F1 hybrid antiparental cytotoxic effector cells: an in vitro model for hemopoietic Histoincompatibility. Science 190, 890, 1975.
C. Riccardi, G. Migliorati and L. Frati: Induction of Naturally Cytotoxic Cells by T-Cell-Growth-Factor: Auto-Cytotoxic Activity Against Syngenic Non-Neoplastic Cells. Proc. 13th International Congress of Chemotherapy, in press, 1983.
J. Tarkkanen: Interferon-evidenced autologous reactivity of human natural killer cells. Scand. J. Immunol., 17, 513, 1983.
C.S. Henney, K. Kuribayashi, P.E. Kern and S. Gillis: Interleukin 2 augments natural killer cell activity. Nature, 291, 335, 1981.
H. Ishikawa and R.W. Dutton: Characterization of the target antigen of F1 antiparent cytotoxic lympholysis: analysis of the spontaneous in vitro F1 cytotoxic T lymphocytes. J.Immunol., 125, 656, 1980.
R. Kiessling, P.S. Hochman, O. Haller, G.M. Shearer, H. Wigzell and G. Cudkowicz: Evidence for a similar or common mechanism for natural killer cell activity and resistance to hemopoietic grafts. Eur. J. Immunol., 7, 655, 1977.
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© 1984 Plenum Press, New York
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Riccardi, C., Migliorati, G., Frati, L., Guadagni, F., Bonmassar, E., Herberman, R.B. (1984). Reactivity of Cultured Mouse Natural Killer (NK) Cells Against Normal Non-Neoplastic Cells. In: Aaronson, S.A., Frati, L., Verna, R. (eds) Genetic and Phenotypic Markers of Tumors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4856-6_13
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DOI: https://doi.org/10.1007/978-1-4684-4856-6_13
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