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Biology and Immunology of Human Carcinoma Cell Populations

  • J. Schlom
  • D. Colcher
  • P. Hand
  • D. Wunderlich
  • M. Nuti
  • R. Mariani-Costantini
  • D. Stramignoni
  • J. Greiner
  • S. Pestka
  • P. Fisher
  • P. Noguchi

Abstract

The rationale for the studies overviewed here was to utilize membrane-enriched extracts of human metastatic mammary tumor cells as immunogens in an attempt to generate and characterize monoclonal antibodies (MAbs) reactive with determinants that would be maintained on primary as well as metastatic human mammary carcinoma cells. Multiple assays have been employed to reveal the range of reactivities and diversity of the various antibodies.

Keywords

Mammary Tumor Athymic Mouse Mammary Tumor Cell Recombinant Interferon Carcinoma Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Barnstable, C., Bodmer, W., Brown, G., Galfre, G., Milstein, C., Williams, A. and Ziegler, A, 1978, Production of monoclonal antibodies to group A erythrocyles, HLA and other human cell surface antigens - new tools for genetic analysis, Cell, 14: 9.PubMedCrossRefGoogle Scholar
  2. Colcher, D., Horan Hand, P., Nuti, M., and J. Schlom, 1981, A spectrum of monoclonal antibodies reactive with human mammary tumor cells, Proc. Natl. Acad. Sci. U.S.A., 73: 3199.CrossRefGoogle Scholar
  3. Colcher, D., Horan Hand, P., Nuti, M., and Schlom, J,, 1983, Differential binding to human mammry and nonmammary tumors of monoclonal antibodies reactive with carcinoembryonic antigen, J. Cancer Invest., 1: 127.CrossRefGoogle Scholar
  4. Colcher, D., Zalutsky, M., Kaplan, W., Kufe, D., Austin, F., and Schlom, J., 1983, Radiolocalization of human mammary tumors in athymic mice by a monoclonal antibody, Cancer Res., 43: 736.Google Scholar
  5. Greiner, J., Horan Hand, P., Noguchi, P., Fisher, P., Pestka, S., and Schlom, J., 1983, Recombinant interferon enhances detection of human breast and colon carcinoma associated antigens by monoclonal antibodies, Science, (Submitted for publication).Google Scholar
  6. Horan Hand, P., Nuti, M., Colcher, D., and Schlom, J., 1983, Definition of antigenic heterogeneity and modulation among human mammary carcinoma cell populations using monoclonal antibodies to tumor-associated antigens, Cancer Res., 43: 728.Google Scholar
  7. Imai, K., Ng, A., Glassy, M, and Ferrone, S., 1981, Differential effect of interferon on the expression of tumor-associated antigens and histocompatibility antigens on human melanoma cells: relationship to susceptibility to immune lysis mediated by monoclonal antibodies J. Immunol., 127: 505.PubMedGoogle Scholar
  8. Kufe, D., Nadler, L., Sargent, L., Shapiro, H., Horan Hand, P., Colcher, D., and Schlom, J., 1983, Biological behavior of human breast carcinomaassociated antigens expressed during cellular proliferation, Cancer Res., 43: 851.PubMedGoogle Scholar
  9. Nuti, M., Colcher, D., Horan Hand, P., Austin, F., and Schlom, J., 1981, Generation and characterization of monoclonal antibodies reactive with human primary and metastatic mammary tumor cells, in “Monoclonal Antibodies and Development in Immunoassay,” A. Albertini and R. Ekins, ed., Elsevier/North Holland Biomedical Press, North Holland.Google Scholar
  10. Nuti, M., Teramoto, Y., Mariani-Costantini, R., Horan Hand, P., Colcher, D., and Schlom, J., 1982, A monoclonal antibody (B72.3) defines patterns of distribution of a novel tumor associated antigen in human mammary carcinoma cell populations, Int. J. Cancer, 29: 539.PubMedCrossRefGoogle Scholar
  11. Pestka, S, 1983, The human interferons - from protein purification and sequence to cloning and expression in bacteria: before, between, and beyond, Arch. Biochem. Biophys., 221: 1.PubMedCrossRefGoogle Scholar
  12. Stramignoni, D., Bowen, R., Atkinson, B. F., and Schlom, J., 1983, Differential reactivity of monoclonal antibodies with human colon adenocarcinomas and adenomas, Int. J. Cancer, 31: 543.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • J. Schlom
    • 1
  • D. Colcher
    • 1
  • P. Hand
    • 1
  • D. Wunderlich
    • 1
  • M. Nuti
    • 1
  • R. Mariani-Costantini
    • 1
  • D. Stramignoni
    • 1
  • J. Greiner
    • 1
  • S. Pestka
    • 1
  • P. Fisher
    • 1
  • P. Noguchi
    • 1
  1. 1.National Cancer InstituteNational Institutes of HealthBethesdaUSA

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