Phenotypic and Genetic Markers of Cancer: Turning Point in Research

  • Luigi Frati
  • Enrico Cortesi
  • Corrado Ficorella
  • Vittorio Manzari
  • Roberto Verna

Abstract

Cancer, after cardiovascular diseases, is the second cause of death both in Europe and U.S.A. Despite efforts and improvements in many fields of tumor research, the surviving time of cancer patients is strongly related to the stage of disease more than to therapeutic strategies.

Keywords

Adduct Sarcoma Estradiol Cytosol Myeloma 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Chu T.M. Ed., 1982 Biochemical Markers for Cancer.Marcel Dekker Inc., New York and BaselGoogle Scholar
  2. Colnaghi M.I., Buraggi G.L. and Ghione M.M. Eds. 1982 Markers for Diagnosis and Monitoring of human cancer. Serono Symp. Vol. 46, Acad. Press, London and New York.Fishman W. Ed., 1983Google Scholar
  3. Oncodevelopmental markers: Biologic, Diagnostic and Monitoring Aspects.Acad. Press, London and New York. Chandra P. Ed., 1983Google Scholar
  4. Biochemical and Biological Markers of neoplastic transformation. Nato Asi series vol. 57, Plenum Press, New York and London.Google Scholar
  5. Russel D.H. and Durie B.G.M. 1978 Polyamines as biochemical markers of normal and malignant growth. Raven Press, New York.Google Scholar
  6. Abelev G.I., 1971 Alpha-Fetoprotein in ontogenesis and its association with malignant tumors.Adv. Cancer Res. 14, 551–558Google Scholar
  7. Cimino F., Russo T., Colonna A. and Salvatore F. 1984 Pseudouridine: a biochemical marker for cancer. This book.Google Scholar
  8. Cole P. and Morrison A.S., 1980 Basic issues in population screening for cancer. J. Natn. Cancer Inst. 64, 1263–1272Google Scholar
  9. Duffy M.Y. O’Connell M., O’Sullivan F., McKenna B., Allen M.A., McDonnell L. 1983 CEA-like material in cytosol from human breast carcinomas. Cancer 51, 121–123PubMedCrossRefGoogle Scholar
  10. Faggioni A., Barile G., Piccoli M. and Frati L. 1984 Epstein-Barr virus markers in nasopharyngeal carcinoma This book.Google Scholar
  11. Fath R.B.jr. and Winawer S.J., 1983 Early diagnosis of colorectal cancer. Ann. Rev. Biochem. 34, 501–517.Google Scholar
  12. Goffeu J., Heistarkamp N., Reynolds F.H. Jr. and Stephenson J.R. 1983: Homology between phosphotyrosine acceptor site of human c-able and viral oncogene products.Nature Vol. 304: 167–169Google Scholar
  13. Goldenberg D.M. 1982 CEA and CSAp Markers in the detection and monitoring of colorectal cancer.In: Colnaghi ET Markers for diagnosis and monitoring of human cancer.Serono Symp. Vol. 46, Acad. Press, London and New York pp. 141–153Google Scholar
  14. Herberman R.B., 1983 Uses and limitations of Tumor Markers.In: Fishman W.H. Ed. Oncodevelopmental markers. Acad. Press. N.Y. pp. 409–418Google Scholar
  15. Holyoke E.D., Evans J.T., Mittleman A. and Chu T.M., 1982 Carcinoembryonic antigen as a tumor marker.In: Chu T.M. Biochemical Markers for cancer. Marcel Dekker Inc., New York and Basel pp. 61–80Google Scholar
  16. Lee Y.T. 1983 Serial tests of carcinoembryonic antigens in patients with breast cancer. Am. J. Clin. Oncol. 6, 287–293PubMedCrossRefGoogle Scholar
  17. Miller D.G., 1976 The early diagnosis of cancer.In: F. Homberger Ed. The pathophysiology of Cancer, Karger, Basel 99. 21–38 Neville A. M. 1982Google Scholar
  18. Ectopic hormone production by tumors in: Chu T.M. Ed. Biochemical Markers for cancer. Marcel Dekker Inc., New York and Basel pp. 267–300 Odell W.D. and Wolfsen A.R. 1978Google Scholar
  19. Reddy E.P., Reynolds R.K., Santos E. and Barbacid M. 1982 A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene.Nature vol.300: 149–152 Schwartz M.K., 1982Google Scholar
  20. Enzymes as tumor markers in: Chu T.M.,Ed. Biochemical Markers for cancer. Marcel Dekker Inc. New York and Basel pp.81–92Google Scholar
  21. Taparowsky B., Suard D., Fasano 0., Shinizy K., Goldforb M. and Wigler M. 1982.Activation of the T24 bladder carcinoma transforming gene linked to a single amino acid change.Nature Vol.300: 762–764 Urushizaki I. and Niitsu Y., 1982Google Scholar
  22. Ferritin in diagnosis of lung cancer.In: Colnaghi I. Eds. Markers for diagnosis and monitoring of human cancer.Serono Symp. Vol. 46 Acad. Press, London and New York pp.111–121Google Scholar
  23. Waterfield M.D., Scrace G.T., Whittle N., Strool P., Jhonsson A., Wastesan A., Westermark B., Mels C.H. and Dewel T.F. 1983: Platelet Derived Growth Factor is structurally related to the putative transforming protein p 28 sis of Simian Sarcoma virus. Nature Vol. 304: 35–39PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Luigi Frati
    • 1
  • Enrico Cortesi
    • 1
  • Corrado Ficorella
    • 1
  • Vittorio Manzari
    • 1
  • Roberto Verna
    • 1
  1. 1.Istituto di Patologia GeneraleUniversità di RomaRomaItaly

Personalised recommendations