Distribution of Gut Peptides and Their Actions

  • Susan M. Wood
Part of the NATO ASI Series book series (volume 80)


Secretin was the first peptide to be identified within the gastrointestinal tract, and provided the prototype for the classical hormones, in that it is released by acid from endocrine cells in the duodenum and passes via the circulation to its effector organ, the exocrine pancreas1. The discovery of gastrin was soon to follow, but it was some twenty years later before further active components were identified from gut extracts. The major limitation of these studies,which showed that intravenous gut extracts could mimic the biological actions normally induced by enteric stimuli,such as acid or food, was the inability at that time to isolate the active substances from the crude extracts. It was not until the 1960s that the techniques of purification and structural analysis pioneered by Gregory and Mutt, allowed investigation of the active substances extracted from the gut, to advance3,4, Many of the classical hormones and a continuing stream of new peptides have now been purified and sequenced by these methods 5,6.


Endocrine Cell Vasoactive Intestinal Polypeptide Enteric Nervous System Pancreatic Polypeptide Glucose Dependent Insulinotropic Peptide 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Susan M. Wood
    • 1
  1. 1.Department of MedicineHammersmith HospitalLondonUK

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