Electrophysiological Studies of Myenteric Neurons in Tissue Culture
The enteric nervous system (ENS) has been the subject of many studies in recent years, and it is now evident that it is highly developed morphologically, pharmacologically and physiologically. Many kinds of neuron have been identified in the ENS with both the light- and the electron- microscope1,2, some 10 putative neurotransmitters have been found by various histochemical methods3,4,5, and up to 8 categories of cells were found by electrophysiological methods6–9.
KeywordsSynaptic Input Vasoactive Intestinal Polypeptide Enteric Nervous System Myenteric Plexus Enteric Neuron
Unable to display preview. Download preview PDF.
- 5.M. Schultzberg, T. Hokfelt, G. Nilsson, L. Terenius, J.H. Rehfeld, M. Brown, R. Eide, M. Goldstein and S. Said, Distribution of peptide- and catecholamine- containing neurons in the gastrointestinal tract of rat and guinea-pig: immunohistochemical studies with antisera to sxabstance P, vasoactive intestinal polypeptider enkephalins, somatostatin, gastrin/cholecysto– kinin, neurotensin and dopamine beta-hydroxyläse, Neuroseience 5:689 (1980).CrossRefGoogle Scholar
- 6.G.D.S. Hirst, M.E. Holman and I. Spence, Two types of neurons in the myenteric plexus of duodenum in the guinea-pig, J. Physiol, (Lond.) 236:303 (1974).Google Scholar
- 7.S. Nishi and R.A. North, Intracellular recording from the my enteric plexus of the guinea-pig ileum, J. Physiol. (Lond.) 231:471 (1973).Google Scholar
- 9.J.D. Wood, Electrophysiology of the enteric nervous system, in: “Physiology of the Gastrointestinal Tract”, L.R. Johnson, ed.. Raven Press, New York (1981).Google Scholar
- 14.K.R. Jessen, M.J. Saffrey, S. Van Noorden, S.R. Bloom, J.M. Polak and G. Bumstock, Immunohistochemical studies of the enteric nervous system in tissue culture and in situ: localization of vasoactive intestinal polypeptide (VIP), substance P and enkephalin immunereactive nerves in the guinea pig gut, Neuroscience 5:1717 (1980).PubMedCrossRefGoogle Scholar
- 19.J.D. Wood and C.J. Mayer, Intracellular study of electrical activity of Auerbach’s plexus in guinea-pig small intestine, Pfluegers Arch. 374;265 (1979).Google Scholar
- 21.S.M. Johnson, Y. Katayama and R.A. North, Slow synaptic poten tials in neurones of myenteric plexus, J. Physiol. (Lond.) 301:505 (1980).Google Scholar
- 24.J.D. Wood, Sensory mechanisms in enteric ganglia, in: “Motility of the Digestive Tract”, M. Wienbeck, ed.. Raven Press, New York (1982).Google Scholar
- 29.S.M. Johnson, Y. Katayama, K. Morita and R.A. North, Mediators of slow synaptic in the myenteric plexus of the guinea-pig ileum, J. Physiol. (Lond.) 32:125 (1981).Google Scholar
- 30.S.M. Johnson, Y. Katayama and R.A. North, Multiple actions of 5-HT on myenteric neurons of the guinea-pig ileum, J. Physiol. (Lond.) 304:459 (1980).Google Scholar
- 33.P.G. Nelson and M. Lieberman, eds., “Excitable Cells in Tissue Culture”, Plenum, New York (1981).Google Scholar