Mechanisms by which Metoclopramide can Increase Gastrointestinal Motility

  • Gareth J. Sanger
Part of the NATO ASI Series book series (volume 80)


Metoclopramide is a dopamine antagonist which has been used for many years in the clinic as an anti-emetic and to increase the motility of the stomach and upper small intestine1,2. However, the mechanisms by which metoclopramide increases gastrointestinal motility are not clearly understood, and may even be unrelated to dopamine antagonism. Studying the actions of metoclopramide is therefore important not only to elucidate the mechanisms, but also to further our understanding of the ways in which gut motility can be controlled. This article describes the different ways in which metoclopramide may increase gastrointestinal motility.


Longitudinal Muscle Gastrointestinal Motility Dopamine Antagonist Submaximal Contraction Cholinergic Response 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Gareth J. Sanger
    • 1
  1. 1.Medicinal Research CentreBeecham PharmaceuticalsHarlow, EssexUK

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